A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract

KIZ OpenIR

	A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract
	Huang, HD; Pu, JL; Zhou, YF; Fan, Y; Zhang, YL; Li, YL; Chen, YZ; Wang, Y; Yu, XM; Dmitry, B; Zhou, Z; Wang, JH
	2024
发表期刊	CLIN EXP PHARMACOL P
ISSN	0305-1870
卷号	51 期号:6
摘要	Chronic hyperglycaemia is a chief feature of diabetes mellitus and complicates with many systematic anomalies. Non-human primates (NHPs) are excellent for studying hyperglycaemia or diabetes and associated comorbidities, but lack behavioural observation. In the study, behavioural, brain imaging and histological analysis were performed in a case of spontaneously hyperglycaemic (HGM) Macaca fascicularis. The results were shown that the HGM monkey had persistent body weight loss, long-term hyperglycaemia, insulin resistance, dyslipidemia, but normal concentrations of insulin, C-peptide, insulin autoantibody, islet cell antibody and glutamic acid decarboxylase antibody. Importantly, an impaired working memory in a delayed response task and neurological dysfunctions were found in the HGM monkey. The tendency for atrophy in hippocampus was observed by magnetic resonance imaging. Lenticular opacification, lens fibres disruptions and vacuole formation also occurred to the HGM monkey. The data suggested that the spontaneous HGM monkey might present diabetes-like characteristics and associated neurobehavioral anomalies in this case. This study first reported cognitive deficits in a spontaneous hyperglycaemia NHPs, which might provide evidence to use macaque as a promising model for translational research in diabetes and neurological complications.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14687
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Huang, HD,Pu, JL,Zhou, YF,et al. A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract[J]. CLIN EXP PHARMACOL P,2024,51(6).
APA	Huang, HD.,Pu, JL.,Zhou, YF.,Fan, Y.,Zhang, YL.,...&Wang, JH.(2024).A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract.CLIN EXP PHARMACOL P,51(6).
MLA	Huang, HD,et al."A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract".CLIN EXP PHARMACOL P 51.6(2024).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
CWT2025042102.pdf（44551KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文