Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer

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	Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer
	Ng, M; Ma, L; Shi, J; Jeffery, WR
	2024
发表期刊	DEVELOPMENT
ISSN	0950-1991
卷号	151 期号:3
摘要	The direction of left-right visceral asymmetry is conserved in vertebrates. Deviations of the standard asymmetric pattern are rare, and the underlying mechanisms are not understood. Here, we use the teleost Astyanax mexicanus, consisting of surface fish with normal left-oriented heart asymmetry and cavefish with high levels of reversed right-oriented heart asymmetry, to explore natural changes in asymmetry determination. We show that Sonic Hedgehog (Shh) signaling is increased at the posterior midline, Kupffer's vesicle (the teleost left-right organizer) is enlarged and contains longer cilia, and the number of dorsal forerunner cells is increased in cavefish. Furthermore, Shh increase in surface fish embryos induces asymmetric changes resembling the cavefish phenotype. Asymmetric expression of the Nodal antagonist Dand5 is equalized or reversed in cavefish, and Shh increase in surface fish mimics changes in cavefish dand5 asymmetry. Shh decrease reduces the level of right-oriented heart asymmetry in cavefish. Thus, naturally occurring modifications in cavefish heart asymmetry are controlled by the effects of Shh signaling on left-right organizer function.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14700
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Ng, M,Ma, L,Shi, J,et al. Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer[J]. DEVELOPMENT,2024,151(3).
APA	Ng, M,Ma, L,Shi, J,&Jeffery, WR.(2024).Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer.DEVELOPMENT,151(3).
MLA	Ng, M,et al."Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer".DEVELOPMENT 151.3(2024).

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QT2025041008.pdf（5320KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文