Characterization of a novel mitophagy-related 5-genes signature for diagnosis of acute myocardial infarction

KIZ OpenIR

	Characterization of a novel mitophagy-related 5-genes signature for diagnosis of acute myocardial infarction
	Xu, YH; Zhu, WQ; Su, Y; Ma, T; Zhang, YQ; Pan, X; Huang, RR; Li, YH; Zuo, KQ; Ong, SB; Xu, DC
	2024
发表期刊	VASC PHARMACOL
ISSN	1537-1891
卷号	156
摘要	Myocardial infarction (MI) and the ensuing heart failure (HF) remain the main cause of morbidity and mortality worldwide. One of the strategies to combat MI and HF lies in the ability to accurately predict the onset of these disorders. Alterations in mitochondrial homeostasis have been reported to be involved in the pathogenesis of various cardiovascular diseases (CVDs). In this regard, perturbations to mitochondrial dynamics leading to impaired clearance of dysfunctional mitochondria have been previously established to be a crucial trigger for MI/HF. In this study, we found that MI patients could be classified into three clusters based on the expression levels of mitophagy-related genes and consensus clustering. We identified a mitophagy-related diagnostic 5-genes signature for MI using support vector machines-Recursive Feature Elimination (SVM-RFE) and random forest, with the area under the ROC curve (AUC) value of the predictive model at 0.813. Additionally, the single-cell transcriptome and pseudo-time analyses showed that the mitoscore was significantly upregulated in macrophages, endothelial cells, pericytes, fibroblasts and monocytes in patients with ischemic cardiomyopathy, while sequestosome 1 (SQSTM1) exhibited remarkable increase in the infarcted (ICM) and non-infarcted (ICMN) myocardium samples dissected from the left ventricle compared with control samples. Lastly, through analysis of peripheral blood from MI patients, we found that the expression of SQSTM1 is positively correlated with troponin-T (P < 0.0001, R = 0.4195, R2 = 0.1759). Therefore, this study provides the rationale for a cell-specific mitophagy-related gene signature as an additional supporting diagnostic for CVDs.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14712
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Xu, YH,Zhu, WQ,Su, Y,et al. Characterization of a novel mitophagy-related 5-genes signature for diagnosis of acute myocardial infarction[J]. VASC PHARMACOL,2024,156.
APA	Xu, YH.,Zhu, WQ.,Su, Y.,Ma, T.,Zhang, YQ.,...&Xu, DC.(2024).Characterization of a novel mitophagy-related 5-genes signature for diagnosis of acute myocardial infarction.VASC PHARMACOL,156.
MLA	Xu, YH,et al."Characterization of a novel mitophagy-related 5-genes signature for diagnosis of acute myocardial infarction".VASC PHARMACOL 156(2024).

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