Recombinant α-Toxin BmK-M9 Inhibits Breast Cancer Progression by Regulating β-Catenin In Vivo

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	Recombinant α-Toxin BmK-M9 Inhibits Breast Cancer Progression by Regulating β-Catenin In Vivo
	Chen, WL; Cha, ZC; Huang, SJ; Liu, RM; Chen, JY; Kamau, PM; Lu, XJ; Li, BW; Liu, DQ
	2025
发表期刊	CELL BIOCHEM BIOPHYS
ISSN	1085-9195
摘要	Screening bioactive compounds from natural sources, including animals and plants, is a valuable strategy for identifying novel anti-tumor agents. alpha-Toxin BmK-M9, a key component of scorpion venom, has received limited attention regarding its potential anti-cancer effects and underlying mechanisms in breast cancer. This study investigates the effects and mechanisms of BmK-M9 in breast cancer using in vitro experiments and a nude mouse model. mRNA sequencing was performed to identify affected signaling pathways, while Western blotting and immunohistochemistry were utilized to analyze the Wnt/beta-catenin signaling pathway. The results demonstrated that BmK-M9 significantly inhibited breast cancer cell invasion and migration in vitro and suppressed tumor growth in vivo. Transcriptomic analysis revealed that BmK-M9 influenced cellular processes related to proliferation, apoptosis, motility, and metabolism. Furthermore, BmK-M9 markedly downregulated beta-catenin expression in the Wnt/beta-catenin pathway. These findings suggest that BmK-M9 exerts anti-tumor effects in breast cancer by modulating Wnt/beta-catenin signaling, highlighting its potential as a promising therapeutic candidate.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14714
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Chen, WL,Cha, ZC,Huang, SJ,et al. Recombinant α-Toxin BmK-M9 Inhibits Breast Cancer Progression by Regulating β-Catenin In Vivo[J]. CELL BIOCHEM BIOPHYS,2025.
APA	Chen, WL.,Cha, ZC.,Huang, SJ.,Liu, RM.,Chen, JY.,...&Liu, DQ.(2025).Recombinant α-Toxin BmK-M9 Inhibits Breast Cancer Progression by Regulating β-Catenin In Vivo.CELL BIOCHEM BIOPHYS.
MLA	Chen, WL,et al."Recombinant α-Toxin BmK-M9 Inhibits Breast Cancer Progression by Regulating β-Catenin In Vivo".CELL BIOCHEM BIOPHYS (2025).

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QT2025041033.pdf（3593KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文