Features and mechanisms of long-lived Myotis somatic fibroblasts in response to DNA replication stress

	Features and mechanisms of long-lived Myotis somatic fibroblasts in response to DNA replication stress
	Huang, XY; Liu, XY; Wang, W; Liu, GJ; Zhu, YL; Wen, X; Li, KQ; Zhao, B
	2025
发表期刊	Zool. Res.
ISSN	2095-8137
卷号	46 期号:3 页码:709-721
摘要	The DNA replication stress (RS) response is crucial for maintaining cellular homeostasis and promoting physiological longevity. However, the mechanisms by which long-lived species, such as bats, regulate RS to maintain genomic stability remain unclear. Also, recent studies have uncovered noncanonical roles of ribosome-associated factors in maintaining genomic stability. In this study, somatic skin fibroblasts from the long-lived big-footed bat (Myotis pilosus) were examined, with results showing that bat cells exhibited enhanced RS tolerance compared to mouse cells. Comparative transcriptome analysis under RS conditions revealed pronounced species-specific transcriptional differences, including robust up-regulation of ribosome biogenesis genes in bat cells and a markedly reduced activation of the P53 signaling pathway. These features emphasize a distinct homeostatic strategy in bat cells. Nuclear fragile X mental retardation-interacting protein 1 (Nufip1), a ribosome-associated factor highly expressed in bat fibroblasts, was identified as a potential integrator of ribosomal and P53 signaling via its association with ribosomal protein S27-like (Rps27l). These findings provide direct cellular and molecular evidence for a noncanonical RS response in bats, highlighting a deeper understanding of the biological characteristics and genomic maintenance mechanisms of long-lived species.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14736
专题	科研部门_基因组稳定调控（赵博）
推荐引用方式 GB/T 7714	Huang, XY,Liu, XY,Wang, W,et al. Features and mechanisms of long-lived Myotis somatic fibroblasts in response to DNA replication stress[J]. Zool. Res.,2025,46(3):709-721.
APA	Huang, XY.,Liu, XY.,Wang, W.,Liu, GJ.,Zhu, YL.,...&Zhao, B.(2025).Features and mechanisms of long-lived Myotis somatic fibroblasts in response to DNA replication stress.Zool. Res.,46(3),709-721.
MLA	Huang, XY,et al."Features and mechanisms of long-lived Myotis somatic fibroblasts in response to DNA replication stress".Zool. Res. 46.3(2025):709-721.

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