| Anti-HIV-1 Activity of the Integrase Strand Transfer Inhibitor ACC017 |
| Ma, MD; Luo, RH; Li, CY; Huang, GC; Long, XY; He, FY; Yang, LM; Fu, HL; Zheng, YT
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| 2025
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| 发表期刊 | Viruses-Basel
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| 卷号 | 18期号:1 |
| 摘要 | HIV-1 integrase strand transfer inhibitors (INSTIs) are pivotal to antiretroviral therapy. However, the emergence of drug-resistant mutations necessitates the development of new agents. Here, we present ACC017 as a novel INSTI candidate. ACC017 demonstrated potent activity against the laboratory-adapted HIV-1IIIB strain (EC50 = 0.59 nM; SI > 34,525) and maintained efficacy against a panel of drug-resistant strains (EC50 range from 0.34 to 9.12 nM) and clinical isolated strains (EC50 range from 0.11 to 1.78 nM). Mechanism of action studies confirmed its ability to inhibit the integrase enzyme (IC50 = 9.19 nM) and effectively block viral genome integration. Notably, in vitro resistance selection primarily yielded D232N and R263K mutations, without the emergence of G140S/A/C/R or Q148H/R/K. This promising profile, combined with synergistic interactions with other antiretroviral drugs, positions ACC017 as a potential therapeutic option. |
| 收录类别 | SCIE
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14806
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| 专题 | 科研部门_分子免疫药理学（郑永唐）
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推荐引用方式
GB/T 7714 |
Ma, MD,Luo, RH,Li, CY,et al. Anti-HIV-1 Activity of the Integrase Strand Transfer Inhibitor ACC017[J]. Viruses-Basel,2025,18(1).
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| APA |
Ma, MD.,Luo, RH.,Li, CY.,Huang, GC.,Long, XY.,...&Zheng, YT.(2025).Anti-HIV-1 Activity of the Integrase Strand Transfer Inhibitor ACC017.Viruses-Basel,18(1).
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| MLA |
Ma, MD,et al."Anti-HIV-1 Activity of the Integrase Strand Transfer Inhibitor ACC017".Viruses-Basel 18.1(2025).
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