| Systems Modeling Reveals Shared Metabolic Dysregulation and Potential Treatments in ME/CFS and Long COVID | |
| Li, GH; Han, FF; Kalafatis, E; Kong, QP; Xiao, WZ | |
| 2025 | |
| 发表期刊 | Int. J. Mol. Sci.
 |
| ISSN | 1661-6596 |
| 卷号 | 26期号:13 |
| 摘要 | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID are complex multisystem conditions that pose significant challenges in healthcare. Accumulated research evidence suggests that ME/CFS and Long COVID exhibit overlapping metabolic symptoms, indicating potential shared metabolic dysfunctions. This study aims to systematically explore shared metabolic disturbances in the muscle tissue of patients. Utilizing genome-wide metabolic modeling, we identified key metabolic irregularities in the muscle of patients with ME/CFS, notably the downregulation of the alanine and aspartate metabolism pathway and the arginine and proline metabolism pathway. Further, in silico knockout analyses suggested that supplementation with aspartate (ASP) or asparagine (ASN) could potentially ameliorate these metabolic deficiencies. In addition, assessments of metabolomic levels in Long COVID patients also showed the significant downregulation of ASP during post-exertional malaise (PEM) in both muscle and blood. Consequently, we propose that a combination of l-ornithine and l-aspartate (LOLA) is a potential candidate to alleviate metabolic symptoms in ME/CFS and Long COVID for future clinical trials. |
| 收录类别 | SCIE |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14818 |
| 专题 | 科研部门_分子人类学（孔庆鹏） |
| 推荐引用方式 GB/T 7714 | Li, GH,Han, FF,Kalafatis, E,et al. Systems Modeling Reveals Shared Metabolic Dysregulation and Potential Treatments in ME/CFS and Long COVID[J]. Int. J. Mol. Sci.,2025,26(13). |
| APA | Li, GH,Han, FF,Kalafatis, E,Kong, QP,&Xiao, WZ.(2025).Systems Modeling Reveals Shared Metabolic Dysregulation and Potential Treatments in ME/CFS and Long COVID.Int. J. Mol. Sci.,26(13). |
| MLA | Li, GH,et al."Systems Modeling Reveals Shared Metabolic Dysregulation and Potential Treatments in ME/CFS and Long COVID".Int. J. Mol. Sci. 26.13(2025). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2026070204.pdf（3190KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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