Genetic diversity and dietary adaptations of the Central Plains Han Chinese population in East Asia

	Genetic diversity and dietary adaptations of the Central Plains Han Chinese population in East Asia
	Qiao, XY; Shi, JX; Xu, HE; Liu, K; Pu, YW; Xue, X; Zheng, WS; Guo, YB; Ma, H; Wang, CC; Bitsue, HK; Xu, XY; Wang, SS; Zhao, JR; Guo, XQ; Hou, XY; Wang, XW; Peng, L; Qiu, Z; Su, B; Tang, WX; He, YX; Guo, JC; Yang, ZH
	2025
发表期刊	Commun. Biol.
卷号	8 期号:1
摘要	The Central Plains Han Chinese (CPHC) is the typical agricultural population of East Asia. Investigating the genome of the CPHC is crucial to understanding the genetic structure and adaptation of the modern humans in East Asia. Here, we perform whole genome sequencing of 492 CPHC individuals and obtained 22.65 million SNPs, 4.26 million INDELs and 41,959 SVs. We found the CPHC has a higher level of genetic diversity and the glycolipid metabolic genes show strong selection signals, e.g. LONP2, FADS2, FGF21 and SLC19A2. Ancient DNA analyses suggest that the domestication of crops, which drove the emergence of the candidate mutations. Notably, East Asian-specific SVs, e.g., DEL_21699 (LINC01749) and DEL_38406 (FAM102A) may be associated with the high prevalence of esophageal squamous carcinoma and primary angle-closure glaucoma. Our results provide an important genetic resource and show that dietary adaptations play an important role in phenotypic evolution in East Asian populations.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15031
专题	科研部门_群体演化基因组学（和耀喜）
推荐引用方式 GB/T 7714	Qiao, XY,Shi, JX,Xu, HE,et al. Genetic diversity and dietary adaptations of the Central Plains Han Chinese population in East Asia[J]. Commun. Biol.,2025,8(1).
APA	Qiao, XY.,Shi, JX.,Xu, HE.,Liu, K.,Pu, YW.,...&Yang, ZH.(2025).Genetic diversity and dietary adaptations of the Central Plains Han Chinese population in East Asia.Commun. Biol.,8(1).
MLA	Qiao, XY,et al."Genetic diversity and dietary adaptations of the Central Plains Han Chinese population in East Asia".Commun. Biol. 8.1(2025).

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