Arachidonic Acid Supplementation During Reproductive Aging Prevents Female Fertility Decline

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	Arachidonic Acid Supplementation During Reproductive Aging Prevents Female Fertility Decline
	Tang, J; Chen, YL; Zhou, M; Zhao, L; Li, YY; Li, MX; Yang, FM; He, ZL; Lv, LB
	2025
发表期刊	Int. J. Mol. Sci.
ISSN	1661-6596
卷号	26 期号:23
摘要	Female reproductive aging precedes physical aging and is closely associated with the development of many aging-related diseases. With the delay in the human reproductive age, delaying reproductive aging and improving fertility have become important challenges for biomedical research. Arachidonic acid (AA) was found to significantly prolong the reproductive lifespan and enhance the quality of senescent oocytes in a cryptic nematode model. In a mouse model of senescence, AA supplementation improved the ovarian reserve, increased the oocyte number and quality, and restored fertility. Further analysis showed that AA delayed ovarian senescence by restoring lysosomal activity in the germ lines of senescent nematodes and mice and enhancing lysosomal functions in oocytes and ovarian granulosa cells. This study provides preliminary evidence that AA could serve as a potential intervention strategy for reproductive senescence and offers new ideas for improving reproductive health in older women.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15159
专题	其他
推荐引用方式 GB/T 7714	Tang, J,Chen, YL,Zhou, M,et al. Arachidonic Acid Supplementation During Reproductive Aging Prevents Female Fertility Decline[J]. Int. J. Mol. Sci.,2025,26(23).
APA	Tang, J.,Chen, YL.,Zhou, M.,Zhao, L.,Li, YY.,...&Lv, LB.(2025).Arachidonic Acid Supplementation During Reproductive Aging Prevents Female Fertility Decline.Int. J. Mol. Sci.,26(23).
MLA	Tang, J,et al."Arachidonic Acid Supplementation During Reproductive Aging Prevents Female Fertility Decline".Int. J. Mol. Sci. 26.23(2025).

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2026071408.pdf（2414KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文