Acer truncatum Bunge seed oil attenuates learning and memory impairment in AD mouse model via modulating gut microbiota and metabolism

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	Acer truncatum Bunge seed oil attenuates learning and memory impairment in AD mouse model via modulating gut microbiota and metabolism
	Ren, DD; Chai, XJ; Xiang, CY; Zhao, YK; Sun, PH; Wang, ML; Li, J; Wu, JY; Yi, CJ; Chen, SL; Li, EY; Zhao, ST
	2026
发表期刊	Front. Nutr.
ISSN	2296-861X
卷号	13
摘要	This study aimed to clarify the neuroprotective effect of Acer truncatum Bunge seed oil (ASO) and its interactions with the gut microbiota in transgenic mice with 5 & times; Familial Alzheimer's disease (5 & times; FAD). The AD-transgenic mice were fed with standard diet supplemented with 4% ASO from one to six months of age. The result show that ASO intervention can alleviate learning and memory impairment, enhance motor coordination and endurance, and reduce A beta deposition in the brains. It also inhibit the proliferation of microglia and astrocytes, decrease the levels of IL-1 beta, IL-6, and TNF-alpha in the hippocampus and serum. Then, ASO could increase the Chao1 index and Shannon index, alter the gut microbiota composition, specifically, enhance the growth of gut bacteria correlated with the production of SCFAs, including Ruminococcaceae, Butyricicoccus, Sutterella and others, particularly those related to butyrate production. Additionally, ASO can increase the concentrations of SCFAs in fresh feces and serum, particularly butyric acid. ASO could primarily modulate the biosynthesis of unsaturated fatty acids, glycerophospholipid metabolism, and sphingolipids metabolism in serum. At the same time, Fecal microbiota transplantation (FMT) could reduce A beta deposition, enhance learning and memory. Finally, Supplementation of sodium Buty also mitigate learning and memory impairments. This study highlights the gut microbiota might be a potential therapeutic target for AD and provides a scientific foundation for developing novel pharmaceuticals or nutraceuticals.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15203
专题	其他
推荐引用方式 GB/T 7714	Ren, DD,Chai, XJ,Xiang, CY,et al. Acer truncatum Bunge seed oil attenuates learning and memory impairment in AD mouse model via modulating gut microbiota and metabolism[J]. Front. Nutr.,2026,13.
APA	Ren, DD.,Chai, XJ.,Xiang, CY.,Zhao, YK.,Sun, PH.,...&Zhao, ST.(2026).Acer truncatum Bunge seed oil attenuates learning and memory impairment in AD mouse model via modulating gut microbiota and metabolism.Front. Nutr.,13.
MLA	Ren, DD,et al."Acer truncatum Bunge seed oil attenuates learning and memory impairment in AD mouse model via modulating gut microbiota and metabolism".Front. Nutr. 13(2026).

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2026071449.pdf（7855KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文