Chromosome-length genome assembly of the stone marten (Martes foina, Mustelidae): A new view on one of the cornerstones in carnivore cytogenetics

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	Chromosome-length genome assembly of the stone marten (Martes foina, Mustelidae): A new view on one of the cornerstones in carnivore cytogenetics
	Tomarovsky, A; Khan, R; Dudchenko, O; Totikov, A; Serdyukova, NA; Weisz, D; Vorobieva, NV; Bulyonkova, T; Abramov, A; Nie, WH; Wang, JH; Romanenko, SA; Proskuryakova, AA; Cherkasov, N; Ferguson-Smith, MA; Yang, FT; Balanovskaya, E; Gilbert, MTP; Graphodatsky, AS; Aiden, EL; Powell, R; Koepfli, KP; Perelman, PL; Kliver, S
	2025
发表期刊	J. Hered.
ISSN	0022-1503
卷号	116 期号:4 页码:548-557
摘要	The stone marten (Martes foina) is an important species for cytogenetic studies in the order Carnivora. ZooFISH probes created from its chromosomes provided a strong and clean signal in chromosome painting experiments and were valuable for studying the evolution of carnivoran genome architecture. The research revealed that the stone marten chromosome set is similar to the presumed ancestral karyotype of the Carnivora, which added an additional value for the species. Using linked-read and Hi-C sequencing, we generated a chromosome-length genome assembly of a male stone marten (Gansu province, China) from a primary cell line. The stone marten assembly had a length of 2.42 Gbp, scaffold N50 of 144 Mbp, and a 96.2% BUSCO completeness score. We identified 19 chromosomal scaffolds (2n = 38) and assigned them chromosome ids based on chromosome painting data. Annotation identified 20,087 protein-coding gene models, of which 18,283 were assigned common names. Comparison of the stone marten assembly with the cat, dog, and human genomes revealed several small syntenic blocks absent on the published painting maps. Finally, we assessed the heterozygosity and its distribution over the chromosomes. The detected low heterozygosity level (0.4 hetSNPs/kbp) and the presence of long runs of homozygosity require further research and a new evaluation of the conservation status of the stone marten in China. Combined with available carnivoran genomes in large-scale synteny analysis, the stone marten genome will highlight new features and events in carnivoran evolution, hidden from cytogenetic approaches.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15208
专题	其他
推荐引用方式 GB/T 7714	Tomarovsky, A,Khan, R,Dudchenko, O,et al. Chromosome-length genome assembly of the stone marten (Martes foina, Mustelidae): A new view on one of the cornerstones in carnivore cytogenetics[J]. J. Hered.,2025,116(4):548-557.
APA	Tomarovsky, A.,Khan, R.,Dudchenko, O.,Totikov, A.,Serdyukova, NA.,...&Kliver, S.(2025).Chromosome-length genome assembly of the stone marten (Martes foina, Mustelidae): A new view on one of the cornerstones in carnivore cytogenetics.J. Hered.,116(4),548-557.
MLA	Tomarovsky, A,et al."Chromosome-length genome assembly of the stone marten (Martes foina, Mustelidae): A new view on one of the cornerstones in carnivore cytogenetics".J. Hered. 116.4(2025):548-557.

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2026071507.pdf（10989KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文