The role of tumor microenvironment and signaling pathways in regulating breast cancer stem cells: Implications for therapy resistance and tumor recurrence

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	The role of tumor microenvironment and signaling pathways in regulating breast cancer stem cells: Implications for therapy resistance and tumor recurrence
	Zhang, HB; Sun, Y; Liu, R; Hamdy, H; Shi, Z; Jiang, DW; Sun, JW
	2026
发表期刊	Drug Resist. Update
ISSN	1368-7646
卷号	84
摘要	Breast cancer stem cells (BCSCs) are recognized as a critical subpopulation involved in cancer recurrence and metastasis, as they are capable of self-renewal and differentiate into various cell types. BCSCs play significant roles in tumor progression, being regulated by key signaling pathways such as Notch, PI3K/AKT/mTOR, and Hedgehog, and their interactions with the tumor microenvironment, which affect tumor growth and resistance to therapeutics. This review focuses on the surface markers of BCSCs, their roles in recurrence and metastasis, and the key signaling pathways. It also discusses the recent progress in understanding how BCSCs contribute to drug resistance and explores potential therapeutic strategies targeting these cells and their microenvironment to improve clinical outcomes and prevent relapse.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15209
专题	其他
推荐引用方式 GB/T 7714	Zhang, HB,Sun, Y,Liu, R,et al. The role of tumor microenvironment and signaling pathways in regulating breast cancer stem cells: Implications for therapy resistance and tumor recurrence[J]. Drug Resist. Update,2026,84.
APA	Zhang, HB.,Sun, Y.,Liu, R.,Hamdy, H.,Shi, Z.,...&Sun, JW.(2026).The role of tumor microenvironment and signaling pathways in regulating breast cancer stem cells: Implications for therapy resistance and tumor recurrence.Drug Resist. Update,84.
MLA	Zhang, HB,et al."The role of tumor microenvironment and signaling pathways in regulating breast cancer stem cells: Implications for therapy resistance and tumor recurrence".Drug Resist. Update 84(2026).

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2026071453.pdf（6856KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文