Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human

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	Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human
	Yang FT 1,2; Graphodatsky AS 3; O'Brien PCM 1; Colabella A 1; Solanky N 1; Squire M 1; Sargan DR 1; Ferguson-Smith MA*1; maf12@mole.bio.cam.ac.uk
	2000
发表期刊	CHROMOSOME RESEARCH
ISSN	0967-3849
卷号	8 期号:5 页码:393-404
合作性质	其它
摘要	Domestic cats and dogs are important companion animals and model animals in biomedical research. The cat has a highly conserved karyotype, closely resembling the ancestral karyotype of mammals, while the dog has one of the most extensively rearranged mammalian karyotypes investigated so far. We have constructed the first detailed comparative chromosome map of the domestic dog and cat by reciprocal chromosome painting. Dog paints specific for the 38 autosomes and the X chromosomes delineated 68 conserved chromosomal segments in the cat, while reverse painting of cat probes onto red fox and dog chromosomes revealed 65 conserved segments. Most conserved segments on cat chromosomes also show a high degree of conservation in G-banding patterns compared with their canine counterparts. At least 47 chromosomal fissions (breaks), 25 fusions and one inversion are needed to convert the cat karyotype to that of the dog, confirming that extensive chromosome rearrangements differentiate the karyotypes of the cat and dog. Comparative analysis of the distribution patterns of conserved segments defined by dog paints on cat and human chromosomes has refined the human/cat comparative genome map and, most importantly, has revealed 15 cryptic inversions in seven large chromosomal regions of conserved synteny between humans and cats.
关键词	Cat Chromosome Painting Comparative Mapping Dog Evolution Human
资助者	A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research. ; A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research. ; A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research. ; A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research.
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收录类别	SCI
语种	中文
资助者	A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research. ; A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research. ; A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research. ; A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/1997
专题	其他
通讯作者	maf12@mole.bio.cam.ac.uk
作者单位	1.Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK 2.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. China 3.Institute of Cytology and Genetics, SB RAS 6300090, Novosibirsk, Russia
推荐引用方式 GB/T 7714	Yang FT,Graphodatsky AS,O'Brien PCM,et al. Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human[J]. CHROMOSOME RESEARCH,2000,8(5):393-404.
APA	Yang FT.,Graphodatsky AS.,O'Brien PCM.,Colabella A.,Solanky N.,...&maf12@mole.bio.cam.ac.uk.(2000).Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human.CHROMOSOME RESEARCH,8(5),393-404.
MLA	Yang FT,et al."Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human".CHROMOSOME RESEARCH 8.5(2000):393-404.

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