Dog chromosome-specific paints reveal evolutionary inter- and intrachromosomal rearrangements in the American mink and human

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	Dog chromosome-specific paints reveal evolutionary inter- and intrachromosomal rearrangements in the American mink and human
	Graphodatsky AS 1; Yang F*2,3; Serdukova N 1; Perelman P 1; Zhdanova NS 1; Ferguson-Smith MA 3; fy@mole.bio.cam.ac.uk
	2000
发表期刊	CYTOGENETICS AND CELL GENETICS
ISSN	0301-0171
卷号	90 期号:3-4 页码:275-278
合作性质	其它
摘要	Forty chromosome-specific paint probes of the domestic dog (Canis familiaris, 2n = 78) were used to delineate conserved segments on metaphase chromosomes of the American mink (Mustela vison, 2n = 30) by fluorescence in situ hybridisation. Half of the 38 canine autosomal probes each painted one pair of homologous segments in a diploid mink metaphase, whereas the other 19 dog probes each painted from two to five pairs of discrete segments. In total, 38 canine autosomal paints highlighted 71 pairs of conserved segments in the mink. These painting results allow us to establish a complete comparative chromosome map between the American mink and domestic dog. This map demonstrates that extensive chromosome rearrangements differentiate the karyotypes of the dog and American mink. The 38 dog autosomes could be reconstructed from the 14 autosomes of the American mink through at least 47 fissions, 25 chromosome fusions, and six inversions. Furthermore, comparison of the current dog/mink map with the published human/dog map discloses 23 cryptic intrachromosomal rearrangements in 10 regions of conserved synteny in the human and American mink genomes and thus further refined the human/mink comparative genome map.
资助者	A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research. ; A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research. ; A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research. ; A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research.
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收录类别	SCI
语种	英语
资助者	A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research. ; A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research. ; A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research. ; A.S.G. and N.Z. are supported by research grants from the Russian Fund for Basic Research.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2001
专题	其他
通讯作者	fy@mole.bio.cam.ac.uk
作者单位	1.Institute of Cytology and Genetics, Novosibirsk (Russia) 2.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan (People’s Republic of China) 3.Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge (UK)
推荐引用方式 GB/T 7714	Graphodatsky AS,Yang F*,Serdukova N,et al. Dog chromosome-specific paints reveal evolutionary inter- and intrachromosomal rearrangements in the American mink and human[J]. CYTOGENETICS AND CELL GENETICS,2000,90(3-4):275-278.
APA	Graphodatsky AS.,Yang F*.,Serdukova N.,Perelman P.,Zhdanova NS.,...&fy@mole.bio.cam.ac.uk.(2000).Dog chromosome-specific paints reveal evolutionary inter- and intrachromosomal rearrangements in the American mink and human.CYTOGENETICS AND CELL GENETICS,90(3-4),275-278.
MLA	Graphodatsky AS,et al."Dog chromosome-specific paints reveal evolutionary inter- and intrachromosomal rearrangements in the American mink and human".CYTOGENETICS AND CELL GENETICS 90.3-4(2000):275-278.

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