分子进化与基因组多样性（张亚平）知识库

通过分析现有的趋化因子和趋化因子受体的氨基酸序列,用距离法和最简约法构建了聚类图,探讨了趋化因子和趋化因子受体基因家族的系统演化特征。可见基因家族成员的分化早于脊椎动物的分化。不同物种的同一种基因的聚类关系能较好地反映物种间的系统发育关系。趋化因子受体的进化速率不同,其中CXCR4的进化速率最低。趋化因子和趋化因子受体可能都起源于少数几个原始的基因。病毒编码与寄主相似的趋化因子或受体是进化过程中分子模拟的结果。

In this study, the phylogenetic trees of chemokines and chemokine receptors are produced, based on distance parsimonious method, using available amino acid sequences from GenBank. The divergence of chemokine or chemokine receptors was earlier than the divergence of vertebrates. While the divergence of homologous genes from different species is in well congruent with phylogenetic relationship of those species. The molecular evolutionary rates of chemokine receptor genes are different, with CXCR4 gene scored the lowest. Chemokines and chemokine receptors originated from few ancient genes. The similarity between the virus encoded chemokines or chemokine receptors with those of host genes is a consequence of evolutionary mimicry.