Biological activities of skin secretions of the salamander Tylototriton verrucosus

	Biological activities of skin secretions of the salamander Tylototriton verrucosus
	Lai R; Yang DM; Lee WH; Zhang Y*; zhangy@mail.kiz.ac.cn
	2002
发表期刊	JOURNAL OF NATURAL TOXINS
ISSN	1058-8108
卷号	11 期号:3 页码:245-250
合作性质	其它
摘要	Water-soluble skin secretions of salamander Tylototriton venucosus, first described by Anderson in 1871, were studied for their biological and enzymatic activities. They were found to be toxic to mice with an intraperitoneal LD50 of 11.5 mg/kg. Using Sephadex G-75 gel filtration, it was proven that the toxic components of the secretions are proteins with molecular weights ranging from 30,000 to 50,000 Da. The secretions of T. venucosus display a wide spectrum of antimicrobial activities and also contain both proteolytic activity and trypsin inhibitory activity. In contrast, neither hemolytic nor hemorrhagic activities were found. The secretions were determined to have phospholipase A(2) activity; however, no acetylcholine esterase activity was detectable under the assay conditions.
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2463
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_生物毒素与人类疾病（张云）
通讯作者	zhangy@mail.kiz.ac.cn
作者单位	Chinese Acad Sci, Kunming Inst Zool, Dept Anim Toxicol, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Lai R,Yang DM,Lee WH,et al. Biological activities of skin secretions of the salamander Tylototriton verrucosus[J]. JOURNAL OF NATURAL TOXINS,2002,11(3):245-250.
APA	Lai R,Yang DM,Lee WH,Zhang Y*,&zhangy@mail.kiz.ac.cn.(2002).Biological activities of skin secretions of the salamander Tylototriton verrucosus.JOURNAL OF NATURAL TOXINS,11(3),245-250.
MLA	Lai R,et al."Biological activities of skin secretions of the salamander Tylototriton verrucosus".JOURNAL OF NATURAL TOXINS 11.3(2002):245-250.

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