Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima

	Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
	Lai R 1; Zheng YT 2; Shen JH 1; Liu GJ 2; Liu H 1; Lee WH 1; Tang SZ 2; Zhang Y*1; zhangy@mail.kiz.ac.cn
	2002
发表期刊	PEPTIDES
ISSN	0196-9781
卷号	23 期号:3 页码:427-435
合作性质	其它
摘要	Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumor cells and spermicidal action of maximins, maximin 3 possessed a significant anti-HIV activity. Maximins 1 and 3 were toxic to mice with LD50 values of 8.2 and 4.3 mg/kg, respectively. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides. cDNA sequences revealed that one maximin peptide plus one maximin H peptide derived from a common larger protein.
关键词	Amphibian Peptide Maximin Antimicrobial Bombina Maxima Cdna Sequence Hiv
资助者	This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M).
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收录类别	SCI
语种	英语
资助者	This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M). ; This work was supported by the grants of “STZ98–3-01,” “Western Light Project” and “Tenth Five Plan” pre-research project from Chinese Academy of Sciences and a grant from Yunnan Science and Technology Commission (2001C0061M).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2467
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_生物毒素与人类疾病（张云）科研部门_分子免疫药理学（郑永唐）
通讯作者	zhangy@mail.kiz.ac.cn
作者单位	1.Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Department of Viral Immunology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
推荐引用方式 GB/T 7714	Lai R,Zheng YT,Shen JH,et al. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima[J]. PEPTIDES,2002,23(3):427-435.
APA	Lai R.,Zheng YT.,Shen JH.,Liu GJ.,Liu H.,...&zhangy@mail.kiz.ac.cn.(2002).Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.PEPTIDES,23(3),427-435.
MLA	Lai R,et al."Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima".PEPTIDES 23.3(2002):427-435.

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