A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima

	A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima
	Lai R; Liu H; Lee WH; Zhang Y*; zhangy@mail.kiz.ac.cn
	2002
发表期刊	PEPTIDES
ISSN	0196-9781
卷号	23 期号:3 页码:437-442
合作性质	其它
摘要	A novel bombesin-related peptide was isolated from skin secretions of Chinese red belly toad Bombina maxima. Its primary structure was established as pGlu-Lys-Lys-Pro-Pro-Arg-Pro-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH(2.) The amino-terminal (N-terminal) 8-residue segment comprising four prolines and three basic residues is extensively different from bombesins from other Bombina species. The peptide was thus named proline rich bombesin (PR-bombesin). PR-bombesin was found to elicit concentration-dependent contractile effects in the rat stomach strip, with both increased potency and intrinsic activity as compared with those of [Leu(13)]bombesin. Analysis of different bombesin cDNA structures revealed that an 8 to 14- nucleotide fragment replacement in the peptide coding region (TGGGGAAT in the cDNAs of multiple bombesin forms from Bombina orientalis and CACCCCGGCCACCC in the cDNA of PR-bombesin) resulted in an unusual Pro-Pro-Arg-Pro-Pro motif in the N-terminal part of PR-bombesin.
关键词	Bombesin Pr-bombesin Amphibian Bombina Maxima Cdna Sequence
资助者	This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M). ; This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M). ; This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M). ; This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M).
URL	查看原文
收录类别	SCI
语种	英语
资助者	This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M). ; This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M). ; This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M). ; This work was supported by the grants of “STZ98–3- 01,” “Western Light Project” and “Tenth Five Plan” pre- research project from Chinese Academy of Sciences; and grants from National Natural Science Foundation (30170195) and Yunnan Science and Technology Commis- sion (2001C0061M).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2469
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_生物毒素与人类疾病（张云）
通讯作者	zhangy@mail.kiz.ac.cn
作者单位	Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 Peoples Republic of China
推荐引用方式 GB/T 7714	Lai R,Liu H,Lee WH,et al. A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima[J]. PEPTIDES,2002,23(3):437-442.
APA	Lai R,Liu H,Lee WH,Zhang Y*,&zhangy@mail.kiz.ac.cn.(2002).A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima.PEPTIDES,23(3),437-442.
MLA	Lai R,et al."A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima".PEPTIDES 23.3(2002):437-442.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
200223437.pdf（129KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文