An opioid peptide from synganglia of the tick, Amblyomma testindinarium

	An opioid peptide from synganglia of the tick, Amblyomma testindinarium
	Liang JG 1; Zhang J 2,3; Lai R*1,2; Rees HH 4; rlai72@njau.edu.cn
	2005
发表期刊	PEPTIDES
ISSN	0196-9781
卷号	26 期号:4 页码:603-606
合作性质	其它
摘要	An opioid peptide, which shares similarity with mammalian hemorphins, has been identified from the synganglia (central nervous system) of the hard tick, Amblyomma testindiarium. Its primary sequence was established as LVVYPWTKM that contains a tetrapeptide sequence Tyr-Pro-Trp-Thr of hemorphin-like opioid peptides. By hot-plate bioassay, the purified peptide and synthetic peptide displayed dose-related antinociceptive effect in mice, as observed for other hemorphin-like opioid peptides. This is the first opioid peptide identified from ticks. Ticks may utilize the opioid peptide in their strategy to escape host immuno-surveillance as well as in inhibiting responses directed against themselves.
关键词	Ticks Synganglia Opioid Peptides Defensive Reaction
资助者	This work was supported by Chinese National Natural Science Foundation (30200044/C01040101). ; This work was supported by Chinese National Natural Science Foundation (30200044/C01040101). ; This work was supported by Chinese National Natural Science Foundation (30200044/C01040101). ; This work was supported by Chinese National Natural Science Foundation (30200044/C01040101).
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收录类别	SCI
语种	英语
资助者	This work was supported by Chinese National Natural Science Foundation (30200044/C01040101). ; This work was supported by Chinese National Natural Science Foundation (30200044/C01040101). ; This work was supported by Chinese National Natural Science Foundation (30200044/C01040101). ; This work was supported by Chinese National Natural Science Foundation (30200044/C01040101).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2475
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
通讯作者	rlai72@njau.edu.cn
作者单位	1.School of Biological Sciences, Nanjing Agriculture University, Nanjing, Jiangshu 210095, China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China 4.School of Biological Sciences, University of Liverpool, The Biosciences Building, Crown Street, Liverpool L69 7ZB, UK
推荐引用方式 GB/T 7714	Liang JG,Zhang J,Lai R*,et al. An opioid peptide from synganglia of the tick, Amblyomma testindinarium[J]. PEPTIDES,2005,26(4):603-606.
APA	Liang JG,Zhang J,Lai R*,Rees HH,&rlai72@njau.edu.cn.(2005).An opioid peptide from synganglia of the tick, Amblyomma testindinarium.PEPTIDES,26(4),603-606.
MLA	Liang JG,et al."An opioid peptide from synganglia of the tick, Amblyomma testindinarium".PEPTIDES 26.4(2005):603-606.

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