Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis

	Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis
	Lu Y 1; Li JX 2,5; Yu HN 3; Xu XQ 2,5; Liang JG 1; Tian YQ 4; Ma DY 2; Lin GQ 1; Huang GQ 2; Lai R*1,2; rlai72@njau.edu.cn
	2006
发表期刊	PEPTIDES
ISSN	0196-9781
卷号	27 期号:12 页码:3085-3091
合作性质	其它
摘要	There are around 27 species of Amolops amphibian distributed in South-east of Asia. Seven antimicrobial peptides (AMPs) belonging to two different families were purified from skin of rufous-spotted torrent frog, Amolops loloensis, and designated brevinins-ALa, b, c, and d, and temporins-ALa, b, and c. The brevinins-AL family which is structurally related to brevinins-1 from skin secretions of the European frog, Rana brevipoda, is composed of 24 amino acids and has an intra-disulfide bridge at the C-terminus. The temporins-AL family, composed of 13 or 16 amino acid residues, is related with temporins from the skin secretions of R. temporaria. The findings of this study will facilitate the solutions to the taxonomic questions of the ranid genus Amolops and Staurois. In the work of this paper, both brevinins-ALb and temporin-Ma induced mast cell degranulation and histamine release, and had cytotoxic activity toward solid tumor cell line HepG2. Brevinins-ALb also exerted strong hemolytic activity while temporin-Ma had no such activity.
关键词	Brevinins-al Temporins-al Amolops Loloensis Amphibian Antimicrobial Peptide Diversity
资助者	This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422).
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收录类别	SCI
语种	英语
资助者	This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yunnan Natural ScienceFoundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2483
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai72@njau.edu.cn
作者单位	1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 2.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.College of Life Sciences School of Heibei Normal University, Shijiazhuang, Hebei 050016, China 4.School of Chemical Engineering, Sichuan University, Chengdu 610051, China 5.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式 GB/T 7714	Lu Y,Li JX,Yu HN,et al. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis[J]. PEPTIDES,2006,27(12):3085-3091.
APA	Lu Y.,Li JX.,Yu HN.,Xu XQ.,Liang JG.,...&rlai72@njau.edu.cn.(2006).Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis.PEPTIDES,27(12),3085-3091.
MLA	Lu Y,et al."Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis".PEPTIDES 27.12(2006):3085-3091.

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