The first report of kininogen from invertebrates

	The first report of kininogen from invertebrates
	Zhou ZH 1,3; Yang HL 1,3; Xu XQ 1,3; Wang X 1; Lai R[*]1,2; rlai72@njau.edu.cn
	2006
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	347 期号:4 页码:1099-1102
合作性质	其它
摘要	The hornet possesses highly toxic venom, which is rich in toxin, enzymes, and biologically active peptides. Several bradykinin-like peptides, vespakinins, have been found in wasp venoms since 1970s, but the mode of biosynthesis of these peptides is unknown. In the present study, a vespakinin M was purified from venom of Vespa magnifica. Its primary sequence was established as GRPPGFSP-FRID. The cDNA encoding the vespakinin M was cloned from the cDNA library of V. magnifica venom gland. The cbNA structure of vespakinin M was found to contain a coding region of 168 nucleotides. The encoded precursor of vespakinin M is composed of a signal peptide, an acidic peptide, and a mature peptide of vespakinin M. This is the first kininogen from insects; it is also the first kininogen from invertebrates. The cDNA structure encoding vespakinin M suggests that the generation mode of bradykinin-related peptides in wasp is different from amphibian skin and mammalian blood system.
关键词	Wasp Vespakinin Kininogen Bradykinin Vespa Magnifica
资助者	This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422).
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收录类别	SCI
语种	英语
资助者	This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422). ; This work was supported by the Chinese National Nat- ural Science Foundation (30570360), Yunnan Natural Sci- ence Foundation (2005C0054M), and Jiangsu Natural Science Foundation (BK2005422).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2487
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai72@njau.edu.cn
作者单位	1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 2.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, Jiangxi, China
推荐引用方式 GB/T 7714	Zhou ZH,Yang HL,Xu XQ,et al. The first report of kininogen from invertebrates[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,347(4):1099-1102.
APA	Zhou ZH,Yang HL,Xu XQ,Wang X,Lai R[*],&rlai72@njau.edu.cn.(2006).The first report of kininogen from invertebrates.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,347(4),1099-1102.
MLA	Zhou ZH,et al."The first report of kininogen from invertebrates".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 347.4(2006):1099-1102.

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