A novel algesic peptide derived from skin secretions of the frog Amolops loloensis

	A novel algesic peptide derived from skin secretions of the frog Amolops loloensis
	Yu HN 1; Wang X 2; Liu JZ1; Lai R2,3; liujingze@mail.hebtu.edu.cn ; rlai@mail.kiz.ac.cn
	2007
发表期刊	JOURNAL OF PEPTIDE SCIENCE
ISSN	1075-2617
卷号	13 期号:12 页码:798-802
合作性质	其它
摘要	Several algesic agents including bradykinin and tachykinin have been identified from skin secretions of amphibians. They may act in defensive roles against aggressors. In this study, a novel peptide named Amolos with an amino acid sequence of FLPIVGAKL and isolated from skin secretion of the frog Amolops loloensis, is shown to strengthen nociceptive responses induced by inflammatory factors and strongly inhibit the contraction of isolated ileum. A synthetic peptide based on the sequence obtained showed characterization data identical to those of the isolated material, confirming its structure. These two types of responses seem to be a part of the defensive functions against predators or aggressors. The current results suggest that pharmacological molecules in amphibian skins not only act as innate defense mechanisms against microorganisms but also exert other defensive physiological functions against other aggressors.
关键词	Amphibian Amolops Loloensis Algesic Ileum Contraction Defence
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2497
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	liujingze@mail.hebtu.edu.cn; rlai@mail.kiz.ac.cn
作者单位	1.College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050016, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 3.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
推荐引用方式 GB/T 7714	Yu HN,Wang X,Liu JZ*,et al. A novel algesic peptide derived from skin secretions of the frog Amolops loloensis[J]. JOURNAL OF PEPTIDE SCIENCE,2007,13(12):798-802.
APA	Yu HN,Wang X,Liu JZ,Lai R,liujingze@mail.hebtu.edu.cn,&rlai@mail.kiz.ac.cn.(2007).A novel algesic peptide derived from skin secretions of the frog Amolops loloensis.JOURNAL OF PEPTIDE SCIENCE,13(12),798-802.
MLA	Yu HN,et al."A novel algesic peptide derived from skin secretions of the frog Amolops loloensis".JOURNAL OF PEPTIDE SCIENCE 13.12(2007):798-802.

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