An antimicrobial peptide with antimicrobial activity against Helicobacter pylori

	An antimicrobial peptide with antimicrobial activity against Helicobacter pylori
	Chen LH 1; Li YH 2; Li JX 3,4; Xu XQ 3,4; Lai R1,3; Zou QM2; rlai@mail.kiz.ac.cn ; qmzou@mail.tmmu.com.cn
	2007
发表期刊	PEPTIDES
ISSN	0196-9781
卷号	28 期号:8 页码:1527-1531
合作性质	其它
摘要	An antimicrobial peptide named odorranain-HP was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLRASSVWGRKYYVDLAGCAKA. By BLAST search, odorranain-HP had similarity to antimicrobial peptide odorranain-W1 but it has a different GLLR N-terminus. The cDNA encoding odorranain-HP was cloned from the cDNA library of the skin of O. grahami. This peptide showed antimicrobial activities against tested microorganisms. Interestingly, odorranain-HP could exert antimicrobial capability against Helicobacter pylori, along with its antimicrobial activities similar to odorranain-W1. This is the first report of naturally occurring peptide with anti-H. pylori activity from amphibian skins.
关键词	Amphibian Antimicrobial Peptide Odorrana Grahami Helicobacter Pylori
资助者	This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences.
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收录类别	SCI
语种	英语
资助者	This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chinese Acad- emy of Sciences.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2503
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai@mail.kiz.ac.cn; qmzou@mail.tmmu.com.cn
作者单位	1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 2.Department of Clinical Immunology and Clinical Microbiology, Third Military Medical University, Chongqing 400038, China 3.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式 GB/T 7714	Chen LH,Li YH,Li JX,et al. An antimicrobial peptide with antimicrobial activity against Helicobacter pylori[J]. PEPTIDES,2007,28(8):1527-1531.
APA	Chen LH.,Li YH.,Li JX.,Xu XQ.,Lai R*.,...&qmzou@mail.tmmu.com.cn.(2007).An antimicrobial peptide with antimicrobial activity against Helicobacter pylori.PEPTIDES,28(8),1527-1531.
MLA	Chen LH,et al."An antimicrobial peptide with antimicrobial activity against Helicobacter pylori".PEPTIDES 28.8(2007):1527-1531.

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