A small trypsin inhibitor from the frog of Odorrana grahami

	A small trypsin inhibitor from the frog of Odorrana grahami
	Li JX 1,4; Wu J 1,4; Wang YP 2,4; Xu XQ 2,4; Liu TG 1; Lai R1,2; Zhu HJ3; rlai@mail.kiz.ac.cn ; hjzhu@mail.kib.ac.cn
	2008
发表期刊	BIOCHIMIE
ISSN	0300-9084
卷号	90 期号:9 页码:1356-1361
合作性质	其它
摘要	A novel peptide inhibitor (OGTI) of serine protease with a molecular weight of 1949.8, was purified from the skin secretion of the frog, Odorrana grahami. Of the tested serine proteases, OGTI only inhibited the hydrolysis activity of trypsin on synthetic chromogenic substrate. This precursor deduced from the cDNA sequence is composed of 70 amino acid residues. The mature OGTI contains 17 amino acid residues including a six-residue loop disulfided by two half-cysteines (AVNIPFKVHFRCKAAFC). In addition to its unique six-residue loop, the overall structure and precursor of OGTI are different from those of other serine protease inhibitors. It is also one of the smallest serine protease inhibitors ever found.
关键词	Serine Protease Inhibitor Amphibian Odorrana Grahami
资助者	This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing. ; This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing. ; This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing. ; This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing.
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收录类别	SCI
语种	英语
资助者	This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing. ; This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing. ; This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing. ; This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2523
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai@mail.kiz.ac.cn; hjzhu@mail.kib.ac.cn
作者单位	1.Tiotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming 650223, Yunnan, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 3.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, CAS, Kunming 650224, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式 GB/T 7714	Li JX,Wu J,Wang YP,et al. A small trypsin inhibitor from the frog of Odorrana grahami[J]. BIOCHIMIE,2008,90(9):1356-1361.
APA	Li JX.,Wu J.,Wang YP.,Xu XQ.,Liu TG.,...&hjzhu@mail.kib.ac.cn.(2008).A small trypsin inhibitor from the frog of Odorrana grahami.BIOCHIMIE,90(9),1356-1361.
MLA	Li JX,et al."A small trypsin inhibitor from the frog of Odorrana grahami".BIOCHIMIE 90.9(2008):1356-1361.

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