An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides

	An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides
	Yan XW 1,2; Feng H 2; Yu HN 1; Yang XL 1; Liu JZ[]1; Lai R[]2,3; jzliu21@heinfo.net ; rltai72@njau.edu.cn
	2008
发表期刊	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN	0145-305X
卷号	32 期号:10 页码:1242-1247
合作性质	其它
摘要	Horseflies are economically important blood-feeding arthropods and also a nuisance for humans, and vectors for filariasis. They rely heavily on the pharmacological propriety of their saliva to get blood meat and suppress immune reactions of hosts. Little information is available on horsefly immune suppressants. By high-performance liquid chromatography (HPLC) purification coupling with pharmacological testing, an immunoregulatory peptide named immunoregulin HA has been identified and characterized from salivary glands of the horsefly of Hybomitra atriperoides (Diptera, Tabanidae). Immunoregulin HA could inhibit the secretion of interferon-gamma (IFN-gamma) and monocyte chemoattractant protein (MCP-1) and increase the secretion of interteukin-10 (IL-10) induced by lipopolysaccharide (LIPS) in rat splenocytes. IL-10 is a suppressor cytokine of T-cell proliferative and cytokine responses. IL-10 can inhibit the elaboration of pro-inflammatory cytokines. Immunoregulin HA possibly unregulated the IL-10 production to inhibit IFN-gamma and MCP-1 secretion in the current experiments. This immunosuppression may facilitate the blood feeding of this horsefly. The current works will facilitate to understand the molecular mechanisms of the ectoparasite-host relationship.
关键词	Horsefly Blood-feeding Cytokine Immunosuppression Ectoparasite-host Relationship
资助者	This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192). ; This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192). ; This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192). ; This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192).
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收录类别	SCI
语种	英语
资助者	This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192). ; This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192). ; This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192). ; This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2527
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	jzliu21@heinfo.net; rltai72@njau.edu.cn
作者单位	1.College of Life Sciences School of Heibei Normal University, Shijiazhuang, Hebei 050016, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 3.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
推荐引用方式 GB/T 7714	Yan XW,Feng H,Yu HN,et al. An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2008,32(10):1242-1247.
APA	Yan XW.,Feng H.,Yu HN.,Yang XL.,Liu JZ[*].,...&rltai72@njau.edu.cn.(2008).An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,32(10),1242-1247.
MLA	Yan XW,et al."An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 32.10(2008):1242-1247.

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