The first antimicrobial peptide from sea amphibian

	The first antimicrobial peptide from sea amphibian
	Lu Y 1; Ma YF 2,3; Xu WA 1; Liang JG 1; Zhang CX 1; Zhang KY 1; Lin GQ 1; Lai R*1,2; rlai@mail.kiz.ac.cn
	2008
发表期刊	MOLECULAR IMMUNOLOGY
ISSN	0161-5890
卷号	45 期号:3 页码:678-681
摘要	The crab-eating frog, Rana cancrivora, is one of only a handful of amphibians worldwide that tolerates saline waters. It typically inhabits brackish water of mangrove forests of Southeast Asia. A large amount of antimicrobial peptides belonging to different families have been identified from skins of amphibians inhabiting freshwater. No antimicrobial peptide from sea amphibians has been reported. In this paper, we firstly reported the antimicrobial peptide and its cDNA cloning from skin secretions of the crab-eating frog R. cancrivora. The antimicrobial peptide was named cancrin with an amino acid sequence of GSAQPYKQLHKVVNWDPYG. By BLAST search, cancrin had no significant similarity to any known peptides. The cDNA encoding cancrin was cloned from the cDNA library of the skin of R. cancrivora. The cancrin precursor is composed of 68 amino acid residues including a signal peptide, acidic spacer peptide, which are similar to other antimicrobial peptide precursors from Ranid amphibians and mature cancrin. The overall structure is similar to other amphibian antimicrobial peptide precursors although mature cancrin is different from known peptides. The current results reported a new family of amphibian antimicrobial peptide and the first antimicrobial peptide from sea amphibian.
关键词	Amphibian Antimicrobial Peptide Rana Cancrivora Sea Amphibian
资助者	This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences.
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收录类别	SCI
语种	英语
资助者	This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences. ; This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Min- istry of Science and Technology of the People’s Republic of China, KSCX2-YW-R-20 and KSCX2-YW-G-024 from Chi- nese Academy of Sciences.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2553
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai@mail.kiz.ac.cn
作者单位	1.College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 2.Biotoxin Department of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式 GB/T 7714	Lu Y,Ma YF,Xu WA,et al. The first antimicrobial peptide from sea amphibian[J]. MOLECULAR IMMUNOLOGY,2008,45(3):678-681.
APA	Lu Y.,Ma YF.,Xu WA.,Liang JG.,Zhang CX.,...&rlai@mail.kiz.ac.cn.(2008).The first antimicrobial peptide from sea amphibian.MOLECULAR IMMUNOLOGY,45(3),678-681.
MLA	Lu Y,et al."The first antimicrobial peptide from sea amphibian".MOLECULAR IMMUNOLOGY 45.3(2008):678-681.

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