Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima

	Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima
	Lai R; Liu H; Lee WH; Zhang Y*; zhangy@mail.kiz.ac.cn
	2003
发表期刊	PEPTIDES
ISSN	0196-9781
卷号	24 期号:2 页码:199-204
合作性质	其它
摘要	A novel 28-amino acid peptide, termed bombinakinin-GAP, was purified and characterized from skin secretions of the toad Bombina maxima. Its primary structure was established as DMYEIKQYKTAHGRPPICAPGEQCPIWV-NH(2), in which two cysteines form a disulfide bond. A FASTA search of SWISS-PROT databank detected a 32% sequence identity between the sequences of the peptide and a segment of rat cocaine- and amphetamine-regulated transcript (CART). Intracerebroventricular (i.c.v.) administration of the peptide induced a significant decrease in food intake in rats, suggesting that it played a role in the control of feeding by brain. Analysis of its cDNA structure revealed that this peptide is coexpressed with bombinakinin M, a bradykinin-related peptide from the same toad. Bombinakinin-GAP appears to be the first example of a novel class of bioactive peptides from amphibian skin, which may be implicated in feeding behavior.
关键词	Amphibian Bombina Maxima Peptide Food Intake Inhibition Bradykinin Bombinakinin-gap
资助者	This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang. ; This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang. ; This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang. ; This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang.
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收录类别	SCI
语种	英语
资助者	This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang. ; This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang. ; This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang. ; This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2657
专题	科研部门_生物毒素与人类疾病（张云）科研部门_天然药物功能蛋白质学科组（赖仞）
通讯作者	zhangy@mail.kiz.ac.cn
作者单位	Department of Animal Toxinology, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming, Yunnan 650223, PR China
推荐引用方式 GB/T 7714	Lai R,Liu H,Lee WH,et al. Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima[J]. PEPTIDES,2003,24(2):199-204.
APA	Lai R,Liu H,Lee WH,Zhang Y*,&zhangy@mail.kiz.ac.cn.(2003).Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima.PEPTIDES,24(2),199-204.
MLA	Lai R,et al."Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima".PEPTIDES 24.2(2003):199-204.

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