Biochemical and biological properties of Trimeresurus jerdonii venom and characterization of a platelet aggregation-inhibiting acidic phospholipase A(2)

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	Biochemical and biological properties of Trimeresurus jerdonii venom and characterization of a platelet aggregation-inhibiting acidic phospholipase A(2)
	Lu QM; Jin Y; Wei JF; Wang WY; Xiong YL*; wangwy@mail.kiz.ac.cn
	2002
发表期刊	JOURNAL OF NATURAL TOXINS
ISSN	1058-8108
卷号	11 期号:1 页码:25-33
合作性质	其它
摘要	Several biochemical and biological activities such as phospholipase A(2), arginine esterase, proteolytic, L-amino acid oxidase, 5'nucleotidase, acetylcholinesterase, thrombin-like, anticoagulant, and hemorrhagic activities were determined for whole desiccated venom of Trimeresurus jerdonii. An acidic phospholipase (named TJ-PLA(2)) was purified by anionic exchange chromatography, gel filtration, and reverse phase HPLC. TJ-PLA(2) had a molecular weight of 16,000 and a pI of 4.8. TJ-PLA(2) was non-lethal to mice up to an i.p. dose of 15 mg/kg body weight and lacked neurotoxicity and myotoxicity. It induced edema in the footpads of mice. The purified enzyme inhibited ADP- and collagen-induced human platelet aggregation in a manner which was both dose- and time-dependent.
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/2803
专题	其他科研部门_天然药物功能蛋白质学科组（赖仞）
通讯作者	wangwy@mail.kiz.ac.cn
作者单位	Chinese Acad Sci, Dept Anim Toxicol, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Lu QM,Jin Y,Wei JF,et al. Biochemical and biological properties of Trimeresurus jerdonii venom and characterization of a platelet aggregation-inhibiting acidic phospholipase A(2)[J]. JOURNAL OF NATURAL TOXINS,2002,11(1):25-33.
APA	Lu QM,Jin Y,Wei JF,Wang WY,Xiong YL*,&wangwy@mail.kiz.ac.cn.(2002).Biochemical and biological properties of Trimeresurus jerdonii venom and characterization of a platelet aggregation-inhibiting acidic phospholipase A(2).JOURNAL OF NATURAL TOXINS,11(1),25-33.
MLA	Lu QM,et al."Biochemical and biological properties of Trimeresurus jerdonii venom and characterization of a platelet aggregation-inhibiting acidic phospholipase A(2)".JOURNAL OF NATURAL TOXINS 11.1(2002):25-33.

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