| Motilin and ghrelin gene experienced episodic evolution during primitive placental mammal evolution | |
| He J1; Irwin MD2; Zhang YP*1,3 | |
| 2010 | |
| 发表期刊 | SCIENCE CHINA-LIFE SCIENCES
 |
| ISSN | 1674-7305 |
| 卷号 | 53期号:6页码:677-682 |
| 合作性质 | 其它 |
| 摘要 | Motilin and ghrelin, members of a structure-function-related hormone family, play important roles in gastrointestinal function, regulation of energy homeostasis and growth hormone secretion. We observed episodic evolution in both of their prehormone gene sequences during primitive placental mammal evolution, during which most of the nonsynonymous changes result in radical substitution. Of note, a functional obestatin hormone might have only originated after this episodic evolution event. Early in placental mammal evolution, a series of biology complexities evolved. At the same time the motilin and ghrelin prehormone genes, which play important roles in several of these processes, experienced episodic evolution with dramatic changes in their coding sequences. These observations suggest that some of the lineage-specific physiological adaptations are due to episodic evolution of the motilin and ghrelin genes. |
| 关键词 | Motilin Ghrelin Episodic Evolution |
| 资助者 | This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Founda- tion of China (Grant Nos. 30621092 and 30623007), and Bureau of Sci- ence and Technology of Yunnan Province. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/4347 |
| 专题 | 科研部门_分子进化与基因组多样性（张亚平） 遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Departments of Laboratory Medicine and Pathobiology and the Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario M5G 2C4, Canada 3.Laboratory for Conservation and Utilization of Bioresource, Yunnan University, Kunming 650091, China |
| 推荐引用方式 GB/T 7714 | He J,Irwin MD,Zhang YP*. Motilin and ghrelin gene experienced episodic evolution during primitive placental mammal evolution[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(6):677-682. |
| APA | He J,Irwin MD,&Zhang YP*.(2010).Motilin and ghrelin gene experienced episodic evolution during primitive placental mammal evolution.SCIENCE CHINA-LIFE SCIENCES,53(6),677-682. |
| MLA | He J,et al."Motilin and ghrelin gene experienced episodic evolution during primitive placental mammal evolution".SCIENCE CHINA-LIFE SCIENCES 53.6(2010):677-682. |
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