Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon

	Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon
	Zheng YT 1; Chan WL 2; Chan P 3; Huang H 2; Tam SC*2; mtam@cuhk.edu.hk
	2001
发表期刊	FEBS LETTERS
ISSN	0014-5793
卷号	496 期号:2-3 页码:139-142
合作性质	其它
摘要	Trichosanthin (TCS) is a type I ribosome-inactivating protein that has a wide range of pharmacological activities. The present study investigated the effectiveness of TCS on herpes simplex virus (HSV-1). The anti-viral activity and toxicity of TCS on Vero cells were measured. Results showed that the ED50, TD50 and the therapeutic indices were 38.5, 416.5 and 10.9 mug/ mi, respectively. Anti-viral activity of TCS was substantially potentiated when it was used in conjunction with other anti-viral agents. The ED50 of TCS was reduced 125-fold by acyclovir at a concentration of 0.001 mug/ml, which was practically devoid of significant anti-viral activity. Similarly, the ED50 of TCS was reduced 100-fold by interferon-alpha 2a at a concentration of 100 IU/ ml. In conclusion, TCS is effective against HSV-1 and other antiviral agents such as acyclovir or interferon can potentiate its action substantially.
关键词	Trichosanthin Ribosome-inactivating Protein Anti-viral Acyclovir Interferon Herpes Simplex Virus
资助者	This work was supported by The Chinese University of Hong Kong Direct Grant 2040855. ; This work was supported by The Chinese University of Hong Kong Direct Grant 2040855. ; This work was supported by The Chinese University of Hong Kong Direct Grant 2040855. ; This work was supported by The Chinese University of Hong Kong Direct Grant 2040855.
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收录类别	SCI
语种	英语
资助者	This work was supported by The Chinese University of Hong Kong Direct Grant 2040855. ; This work was supported by The Chinese University of Hong Kong Direct Grant 2040855. ; This work was supported by The Chinese University of Hong Kong Direct Grant 2040855. ; This work was supported by The Chinese University of Hong Kong Direct Grant 2040855.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4519
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	mtam@cuhk.edu.hk
作者单位	1.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 2.Department of Physiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China 3.Department of Microbiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China
推荐引用方式 GB/T 7714	Zheng YT,Chan WL,Chan P,et al. Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon[J]. FEBS LETTERS,2001,496(2-3):139-142.
APA	Zheng YT,Chan WL,Chan P,Huang H,Tam SC*,&mtam@cuhk.edu.hk.(2001).Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon.FEBS LETTERS,496(2-3),139-142.
MLA	Zheng YT,et al."Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon".FEBS LETTERS 496.2-3(2001):139-142.

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