Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

	Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha
	Li RT 1; Han QB 1; Zheng YT 2; Wang RR 2; Yang LM 2; Lu Y 3; Sang SQ 3; Zheng QT 3; Zhao QS 1; Sun HD[*]1; hdsun@mail.kib.ac.cn
	2005
发表期刊	CHEMICAL COMMUNICATIONS
ISSN	1359-7345
期号	23 页码:2936-2938
合作性质	其它
摘要	Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C ( 2) exhibited an EC50 value of 7.71 mu g/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.
资助者	This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng. ; This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng. ; This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng. ; This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng.
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收录类别	SCI
语种	英语
资助者	This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng. ; This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng. ; This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng. ; This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4541
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	hdsun@mail.kib.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China 2.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, P. R. China 3.Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050, P. R. China
推荐引用方式 GB/T 7714	Li RT,Han QB,Zheng YT,et al. Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha[J]. CHEMICAL COMMUNICATIONS,2005(23):2936-2938.
APA	Li RT.,Han QB.,Zheng YT.,Wang RR.,Yang LM.,...&hdsun@mail.kib.ac.cn.(2005).Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha.CHEMICAL COMMUNICATIONS(23),2936-2938.
MLA	Li RT,et al."Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha".CHEMICAL COMMUNICATIONS .23(2005):2936-2938.

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