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Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities
Wang JS1; Zheng YT2; Efferth T3; Wang RR2; Shen YM1; Hao XJ*1; haoxj@mail.kib.ac.cn
2005
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号66期号:6页码:697-701
合作性质其它
摘要A diprenylated indole, (E)-3-(3-hydroxymethyl-2-butenyl)-7-(3-methyl-2-butenyl)-1H-indole (1), and six known carbazole alkaloids were isolated from the twigs and leaves of Glycosmis montana Pierre (Rutaceae). Their structures were determined on the basis of analysis of spectral evidence including 1D and 2D NMR and MS. The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM.
关键词Glycosmis Montana Rutaceae Diprenylated Indole Carbozole Anti-hiv C8166 Cytotoxicity Leukaemia
资助者The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142).
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收录类别SCI
语种英语
资助者The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). ; The work was supported by grants from the Key Technologies R&D programme of Yunnan (2004NG12); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142).
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/4547
专题科研部门_分子免疫药理学(郑永唐)
通讯作者haoxj@mail.kib.ac.cn
作者单位1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongton, Kunming, Yunnan 650204, PR China
2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China
3.German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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Wang JS,Zheng YT,Efferth T,et al. Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities[J]. PHYTOCHEMISTRY,2005,66(6):697-701.
APA Wang JS.,Zheng YT.,Efferth T.,Wang RR.,Shen YM.,...&haoxj@mail.kib.ac.cn.(2005).Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.PHYTOCHEMISTRY,66(6),697-701.
MLA Wang JS,et al."Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities".PHYTOCHEMISTRY 66.6(2005):697-701.
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