Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica

	Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica
	Qin XD 1; Dong ZJ 1; Liu JK1; Yang LM 2; Wang RR 2; Zheng YT2; Lu Y 3; Wu YS 3; Zheng QT 3; jkliu@mail.kib.ac.cn ; zhengyt@mail.kiz.ac.cn
	2006
发表期刊	HELVETICA CHIMICA ACTA
ISSN	0018-019X
卷号	89 期号:1 页码:127-133
合作性质	其它
摘要	A novel benzofuran lactone, named concentricolide (=rel-(6R)-6-ethylbenzo[2.1-b:3,4-c']difuran-8(6H)-one; 1), was isolated along with four known compounds (friedelin, cytochalasin L-696.474, armillaramide, and russulamide) from the fruiting bodies of the xylariaceous ascomycete Daldinia concentrica. The structure of I was established by spectroscopic methods and X-ray crystallographic analysis. Its anti-HIV-1 activity was tested. Results showed that 1 inhibited HIV-1 induced cytopathic effects. The EC50 value was 0.31 mu g/ml. The therapeutic index (TI) was 247. Concentricolide exhibited the blockage (EC50 0.83 mu g/ml) on syncytium formation between HIV-1 infected cells and normal cells.
资助者	This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng. ; This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng. ; This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng. ; This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng.
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收录类别	SCI
语种	英语
资助者	This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng. ; This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng. ; This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng. ; This work was supported by contributions of the National Natural Science Foundation of China (30470027 and 30225048) to Dr. J.-K. Liu and of the Key Scientific and Technological projects of China (2004BA719A14) and Yunnan Province (2004NG12), and 863 Program (2003AA219142) to Dr. Y. T. Zheng.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4573
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	jkliu@mail.kib.ac.cn; zhengyt@mail.kiz.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P. R. China 3.Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, P. R. China
推荐引用方式 GB/T 7714	Qin XD,Dong ZJ,Liu JK*,et al. Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica[J]. HELVETICA CHIMICA ACTA,2006,89(1):127-133.
APA	Qin XD.,Dong ZJ.,Liu JK*.,Yang LM.,Wang RR.,...&zhengyt@mail.kiz.ac.cn.(2006).Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica.HELVETICA CHIMICA ACTA,89(1),127-133.
MLA	Qin XD,et al."Concentricolide, an anti-HIV agent from the ascomycete Daldinia concentrica".HELVETICA CHIMICA ACTA 89.1(2006):127-133.

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