Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera

	Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera
	Xiao WL 1; Yang LM 2; Li LM 1; Pu JX 1; Huang SX 1; Weng ZY 1; Lei C 1; Liu JP 1; Wang RR 2; Zheng YT 2; Li RT 1; Sun HD*1; hdsun@mail.kib.ac.cn
	2007
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	48 期号:31 页码:5543-5546
合作性质	其它
摘要	Four novel highly oxygenated trinortriterpenoids, sphenalactones A-D (1-4), were isolated from the leaves and stems of Schisandra sphenanthera and their structures were elucidated by extensive analysis of 1D and 2D NMR data. Compounds 1-4 featured a C-27 backbone and showed anti-HIV-1 activity with EC50 values in the range of 35.5-89.1 mu g/mL with low cytotoxicity against C8166 cells (CC50 > 200 mu g/mL).
关键词	Schisandra Sphenanthera Sphenalactones A-d Trinortriterpenoid Anti-hiv Activity
资助者	This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao). ; This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao). ; This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao). ; This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao).
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收录类别	SCI
语种	英语
资助者	This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao). ; This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao). ; This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao). ; This work was supported by grants from the Yong Aca- demic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), Key Scientific and Technological projects of China (2004BA719A14), the National Natural Sci- ence Foundation of China (No. 20402016) and project of Chinese Academy of Sciences (KSCX1-YW-R-24 and XiBuZhiGuang to W.-L., Xiao).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4587
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	hdsun@mail.kib.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204 Yunnan, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, PR China
推荐引用方式 GB/T 7714	Xiao WL,Yang LM,Li LM,et al. Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera[J]. TETRAHEDRON LETTERS,2007,48(31):5543-5546.
APA	Xiao WL.,Yang LM.,Li LM.,Pu JX.,Huang SX.,...&hdsun@mail.kib.ac.cn.(2007).Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera.TETRAHEDRON LETTERS,48(31),5543-5546.
MLA	Xiao WL,et al."Sphenalactones A-D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera".TETRAHEDRON LETTERS 48.31(2007):5543-5546.

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