| Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives | |
| Chen SW1,3; Wang YH2,4; Jin Y1; Tian X*1; Zheng YT*2; Luo DQ2; Tu YQ*1; xuant@lzu.edu.cn | |
| 2007 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| ISSN | 0960-894X |
| 卷号 | 17期号:7页码:2091-2095 |
| 合作性质 | 其它 |
| 摘要 | In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 119d and 19c showed the highest anti-HIV-1 activities with EC50 values of 0.17 and 0.29 mu M and TI values of 466.9 and 354.5, respectively. |
| 关键词 | Podophyllotoxin D4t Anti-hiv Totoxicity |
| 资助者 | This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). ; This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). ; This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). ; This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). ; This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). ; This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). ; This work has been supported by the Interdisciplinary Innovation Research Fund For Young Scholars, Lanz- hou University (LZU200526); Natural Science Founda- tion of Yunnan Province (2003C0022R); Key Scientific and Technological Projects of China (2004BA719A14) and Yunnan Province (2004NG12). |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/4601 |
| 专题 | 科研部门_分子免疫药理学（郑永唐） |
| 通讯作者 | xuant@lzu.edu.cn |
| 作者单位 | 1.State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China 2.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 3.School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China 4.Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China |
| 推荐引用方式 GB/T 7714 | Chen SW,Wang YH,Jin Y,et al. Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(7):2091-2095. |
| APA | Chen SW.,Wang YH.,Jin Y.,Tian X*.,Zheng YT*.,...&xuant@lzu.edu.cn.(2007).Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(7),2091-2095. |
| MLA | Chen SW,et al."Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.7(2007):2091-2095. |
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