Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques

	Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques
	Ouyang DY 1; Xu LH 2; Dai ZX 3,4; Shi HJ 1; Zhang GH 3; Zheng YT3; He XH1; zhengyt@mail.kiz.ac.cn ; thexh@jnu.edu.cn
	2008
发表期刊	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN	1672-9145
卷号	40 期号:11 页码:919-927
合作性质	其它
摘要	Major histocompatibility complex (MHC) class I information is vital for understanding variance of immune responses in HIV vaccination and biomedical models. In this study, 9 Mamu-A and 13 Mamu-B alleles were identified from the cDNA products of 10 Chinese-origin rhesus macaques. Except for two alleles that had been reported by others, eight were novel and twelve extended the partial sequences that are available in GenBank. The additional information of MHC class I antigens might be beneficial to the availability of Chinese macaques in human disease studies. Furthermore, the polymorphism of leading peptides and the natural killer receptor recognition motifs in alpha 1 domain both implies that Mamu-A and Mamu-B molecules might play key roles in innate immune responses of natural killer cells.
关键词	Mamu-a Mamu-b Mhc Class i Rhesus Macaque
资助者	This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province ; This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province ; This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province ; This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province
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语种	英语
资助者	This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province ; This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province ; This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province ; This work was supported by the grants from the National Natural Science Foundation of China (No. 30572199, No. 30230350 and No. 30371651) to Prof. XH He; the Talented Man Initiation Fund of Jinan University (No. 51208004 and No. 51208017) and Natural Science Fund of Guangdong Province (No. 8451063201000340) to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan (2004NG12 and 2006PT08), the Major State Basic Research Development Program of China (2006CB504208), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15) to Dr. YT Zheng, and “Western Light” Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4615
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn; thexh@jnu.edu.cn
作者单位	1.Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, Chin 2.Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China 3.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Ouyang DY,Xu LH,Dai ZX,et al. Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2008,40(11):919-927.
APA	Ouyang DY.,Xu LH.,Dai ZX.,Shi HJ.,Zhang GH.,...&thexh@jnu.edu.cn.(2008).Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,40(11),919-927.
MLA	Ouyang DY,et al."Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 40.11(2008):919-927.

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