Compounds from Kadsura heteroclita and related anti-HIV activity

	Compounds from Kadsura heteroclita and related anti-HIV activity
	Pu JX 1; Yang LM 2; Xiao WL 1; Li RT 3; Lei C 1; Gao XM 1; Huang SX 1; Li SH 1; Zheng YT 2; Huang H 4; Sun HD*1; hdsun@mail.kib.ac.cn
	2008
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	69 期号:5 页码:1266-1272
合作性质	其它
摘要	Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipcdlactone J (2), and two dibenzocyclooctadiene type lignans named heteroclitin I and J (3, 4). Compounds 8-10, 14, and 15 were weakly active as anti-HIV agents, whereas compounds 6 and 12 exhibited moderate anti-HIV activity with EC(50) values of 1.6 mu g/mL, and 1.4 mu g/mL, therapeutic index (TI) values of 52.9, and 65.9, respectively. Their structures were established by spectroscopic methods, including application of 2D NMR techniques and CD spectra.
关键词	Kadsura Heteroclita Schisandraceae Triterpenoid Dibenzocyclooctadiene Type Lignans Anti-hiv-1 Activity
资助者	We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12). ; We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12). ; We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12). ; We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12).
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收录类别	SCI
资助者	We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12). ; We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12). ; We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12). ; We gratefully acknowledge to the support of the Yong Academic and Technical Leader Raising Foundation of Yunnan Province (2006PY01-47), the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), the National Natural Science Foundation of China (20402016), and the key Scientific and Technolog- ical projects of Yunnan province (2004NG12).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4645
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	hdsun@mail.kib.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China 2.Laboratory of Molecular Immunopharmacology, key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China 3.Kunming University of Science and Technology, Kunming 650204, Yunnan, PR China 4.Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China
推荐引用方式 GB/T 7714	Pu JX,Yang LM,Xiao WL,et al. Compounds from Kadsura heteroclita and related anti-HIV activity[J]. PHYTOCHEMISTRY,2008,69(5):1266-1272.
APA	Pu JX.,Yang LM.,Xiao WL.,Li RT.,Lei C.,...&hdsun@mail.kib.ac.cn.(2008).Compounds from Kadsura heteroclita and related anti-HIV activity.PHYTOCHEMISTRY,69(5),1266-1272.
MLA	Pu JX,et al."Compounds from Kadsura heteroclita and related anti-HIV activity".PHYTOCHEMISTRY 69.5(2008):1266-1272.

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