Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia

	Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia
	Chen JC 1,3; Tian RR 2; Qiu MH*1; Lu L 1,3; Zheng YT 2; Zhang ZQ 1,3; mhchiu@mail.kib.ac.cn
	2008
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	69 期号:4 页码:1043-1048
合作性质	其它
摘要	Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3 beta,7 beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3 beta,25-dihydroxy-5 beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 mu g/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50) > 200 mu g/ml), with a selectivity index more than 23.68 and 7.81, respectively.
关键词	Momordica Charantia Cucurbitaceae Roots Kuguacins A-e Trinorcucurbitane Triterpenoids Anti-hiv-1
资助者	The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support.
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收录类别	SCI
语种	英语
资助者	The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (Grant No. 39970086), Program of Promoting Development for Guizhou (QIAN 01-2005-01), and the Chinese Academy of Sciences (XiBuZhiGuang Project) for financial support.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4649
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	mhchiu@mail.kib.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
推荐引用方式 GB/T 7714	Chen JC,Tian RR,Qiu MH*,et al. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia[J]. PHYTOCHEMISTRY,2008,69(4):1043-1048.
APA	Chen JC.,Tian RR.,Qiu MH*.,Lu L.,Zheng YT.,...&mhchiu@mail.kib.ac.cn.(2008).Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia.PHYTOCHEMISTRY,69(4),1043-1048.
MLA	Chen JC,et al."Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia".PHYTOCHEMISTRY 69.4(2008):1043-1048.

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