Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China

	Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China
	Tu YQ; Wang MJ; Yao J; Zhu XM; Pan PL; Xing WG; Zhang GH; Yang RG; Zheng YT; Jiang Y; zhengyt@mail.kiz.ac.cn; jiangyan03@263.net
	2009
发表期刊	TRANSFUSION
ISSN	0041-1132
卷号	49 期号:9 页码:1865-1873
合作性质	其它
摘要	BACKGROUND: Drug resistance profiles of human immunodeficiency virus-1 (HIV-1) in treatment-naive infections have been reported in developed countries. However, little is known in developing countries, including China, especially in treatment-naive volunteer blood donors. STUDY DESIGN AND METHODS: Fifty-two HIV-1 positive samples of blood donors were collected from 2005 to 2006 in Yunnan, China. Recent and long-term infections were distinguished by the HIV-1 subtypes B, E, and D immunoglobulin G-capture enzyme immunoassay assay. The nucleotide sequences of pol genes were amplified and sequenced. Phylogenetic tree and drug resistance analyses were performed. RESULTS: Of 49 samples successfully analyzed, circulating strains were circulating recombinant form (CRF) 08_BC (51.0%), CRF07_BC (24.5%), CRF01_AE (20.4%), and B (4.1%). No protease inhibitors (PI) major drug resistance mutation (DRM) was detected. Six samples (12.2%) displayed seven minor PI DRMs. Nine samples (18.4%) displayed 10 nucleoside reverse transcriptase inhibitor DRMs, and DRMs to nonnucleoside reverse transcriptase inhibitors were present in one sample (2.0%). There was only one sample of the 49 (2.0%) in which the DRMs were of sufficient magnitude to result in a clinical change to drug susceptibility, but even in this sample, the clinical effect of these DRMs was predicted to be low. Significant differences were not observed between the long-term and recent infected population. Differences in DRMs were not observed between peripheral blood mononuclear cells and plasma within an individual. CONCLUSIONS: CRF_BC was the dominant subtype circulating in HIV-1-infected donors in Yunnan. Prevalence of genotypic drug resistances among donors in Yunnan was low in this study. Surveillance on HIV-1 infections among blood donors should be continued in China.
资助者	The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14). ; The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14). ; The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14). ; The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14).
收录类别	SCI
语种	英语
资助者	The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14). ; The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14). ; The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14). ; The work was supported by grants from National 973 project of China (2006CB504208, 2006CB504302), the Natural Science Foundation of China (30671960, U0832601), and Key Scientific and Technological projects of China (2004BA719A14).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4661
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn; jiangyan03@263.net
推荐引用方式 GB/T 7714	Tu YQ,Wang MJ,Yao J,et al. Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China[J]. TRANSFUSION,2009,49(9):1865-1873.
APA	Tu YQ.,Wang MJ.,Yao J.,Zhu XM.,Pan PL.,...&jiangyan03@263.net.(2009).Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China.TRANSFUSION,49(9),1865-1873.
MLA	Tu YQ,et al."Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China".TRANSFUSION 49.9(2009):1865-1873.

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