Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis

	Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis
	Li XN 1,4; Pu JX 1; Du X 1; Yang LM 2; An HM 3; Lei C 1; He F 1; Luo X 1; Zheng YT 2; Lu Y 3; Xiao WL1; Sun HD1; hdsun@mail.kib.ac.cn ; xwl@mail.kib.ac.cn
	2009
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	72 期号:6 页码:1133-1141
合作性质	其它
摘要	Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 mu M and a therapeutic index (TI) of more than 25.
资助者	This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS ; This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS ; This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS ; This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS
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收录类别	SCI
语种	英语
资助者	This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS ; This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS ; This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS ; This work was supported financially by the NSFC (No. 30830115 and 20802082), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), a project of the Chinese Academy of Sciences ("Xibuzhiguang" to W.L.X. and No. KS
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4667
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	hdsun@mail.kib.ac.cn; xwl@mail.kib.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China 3.Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking 100050, People’s Republic of China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100039, People’s Republic of China
推荐引用方式 GB/T 7714	Li XN,Pu JX,Du X,et al. Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(6):1133-1141.
APA	Li XN.,Pu JX.,Du X.,Yang LM.,An HM.,...&xwl@mail.kib.ac.cn.(2009).Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis.JOURNAL OF NATURAL PRODUCTS,72(6),1133-1141.
MLA	Li XN,et al."Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis".JOURNAL OF NATURAL PRODUCTS 72.6(2009):1133-1141.

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