Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro

	Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro
	Fan LL 1; Liu WQ 2; Xu H[]1; Yang LM 2; Lv M[]1; Zheng YT[*]2; orgxuhui@nwsuaf.edu.cn ; lvmin@nwsuaf.edu.cn ; zhengyt@mail.kiz.ac.cn
	2009
发表期刊	LETTERS IN DRUG DESIGN & DISCOVERY
ISSN	1570-1808
卷号	6 期号:3 页码:178-180
合作性质	其它
摘要	Ten dibenzofurans were synthesized and evaluated as human immunodeficiency virus (HIV)-1 inhibitors in vitro for the first time. Among these compounds, compounds 1, 6, 7 and 8 demonstrated significant anti-HIV-1 activity. Especially compound 1 showed the highest anti-HIV-1 activity with TI value larger than 16.18. Meanwhile, some structure-activity relationships were also observed and will provide a new lead for design and discovery of more potent dibenzofurans as new HIV-1 inhibitors.
关键词	Dibenzofuran Human Immunodeficiency Virus Inhibitor Synthesis
学科领域	Chemistry, Medicinal
资助者	This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24). ; This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24). ; This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24). ; This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24).
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收录类别	SCI
语种	英语
资助者	This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24). ; This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24). ; This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24). ; This work has been supported by the program for New Century Excellent University Talents, State Education Min- istry of China (NCET-06-0868), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20070712025), State Education Ministry of China. We also would like to acknowledge Key Scientific and Technological Projects of China (2008ZX10001; 2008ZX10501), National 973 project of China (2009CB522300), and The Knowledge Innovation Program of CAS (KSCX1-YW-R-24).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4671
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	orgxuhui@nwsuaf.edu.cn; lvmin@nwsuaf.edu.cn; zhengyt@mail.kiz.ac.cn
作者单位	1.Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P.R. China 2.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R. China
推荐引用方式 GB/T 7714	Fan LL,Liu WQ,Xu H[*],et al. Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2009,6(3):178-180.
APA	Fan LL.,Liu WQ.,Xu H[].,Yang LM.,Lv M[].,...&zhengyt@mail.kiz.ac.cn.(2009).Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro.LETTERS IN DRUG DESIGN & DISCOVERY,6(3),178-180.
MLA	Fan LL,et al."Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro".LETTERS IN DRUG DESIGN & DISCOVERY 6.3(2009):178-180.

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