Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum

	Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum
	Lin HW 1; Sun MX 1; Wang YH 2; Yang LM 2; Yang YR 2; Huang N 2; Xuan LJ 3; Xu YM 3; Bai DL 3; Zheng YT2; Xiao K1; zhengyt@mail.kiz.ac.cn ; kaixiaocn@gmail.com
	2010
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	76 期号:9 页码:889-892
合作性质	其它
摘要	The 70% EtOH extract of Polygonum cuspidatum showed inhibitory action against HIV-1-induced syncytium formation at non-cytotoxic concentrations in vitro with a 50% effective concentration (EC50) of 13.94 +/- 3.41 mu g/mL. Through bioactivity-guided fractionation, 20 phenolic compounds, including eight stilbenoids, were isolated from the roots of Polygonum cuspidatum, and their anti-HIV-1 activities were evaluated. Results showed that compounds 1, 13, 14, and 16 demonstrated fairly strong antiviral activity against HIV-1-induced cytopathic effects in C8166 lymphocytes at non-cytotoxic concentrations, with EC50 values of 4.37 +/- 1.96 mu g/mL, 19.97 +/- 5.09, 14.4 +/- 1.34 mu g/mL, and 11.29 +/- 6.26 mu g/mL and therapeutic index (TI) values of 8.12, > 10.02, > 13.89, and > 17.71, respectively. Other compounds showed either weak or no effects. Compound 6 also showed weak inhibition (153.42 +/- 19.25 mu g/mL); however, it possesses very good water solubility and showed almost no cytotoxicity (> 2000 mu g/mL), therefore achieving a fairly good TI (13.04). The activities of the two compounds (3 and 18) from Polygonum multiflorum were also assayed. The relationship between molecular structures and their bioactivities was also discussed.
关键词	Polygonum Cuspidatum Polygonum Multiflorum Polygonaceae Chemical Components Anti-hiv-1 Activity
资助者	This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province.
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收录类别	SCI
资助项目	Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum
资助者	This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province. ; This work was supported by the National Basic Research Program of China (Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007), and Bureau of Science and Technology of Yunnan Province.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4685
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn; kaixiaocn@gmail.com
作者单位	1.Lab of Toxicology & Pharmacology, Faculty of Naval Medicine, The Second Military Medical University, Shanghai, P.R. China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Insti- tute of Zoology, Chinese Academyof Sciences, Kunming, P.R. China 3.Shanghai Institute ofMateria Medica, Shanghai Institutes for Biolog- ical Sciences, Chinese Academy of Sciences, Shanghai, P.R. China
推荐引用方式 GB/T 7714	Lin HW,Sun MX,Wang YH,et al. Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum[J]. PLANTA MEDICA,2010,76(9):889-892.
APA	Lin HW.,Sun MX.,Wang YH.,Yang LM.,Yang YR.,...&kaixiaocn@gmail.com.(2010).Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum.PLANTA MEDICA,76(9),889-892.
MLA	Lin HW,et al."Anti-HIV Activities of the Compounds Isolated from Polygonum cuspidatum and Polygonum multiflorum".PLANTA MEDICA 76.9(2010):889-892.

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