| Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata | |
| Feng T1,2; Wang RR3; Cai XH1; Zheng YT*3; Luo XD*1; zhengyt@mail.kiz.ac.cn | |
| 2010 | |
| 发表期刊 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| ISSN | 0009-2363 |
| 卷号 | 58期号:7页码:971-975 |
| 合作性质 | 其它 |
| 摘要 | A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65. |
| 关键词 | Poncirus Trifoliata Chemical Constituent Prenylated Flavonoid Anti-human Immunodeficiency Virus-1 Activity |
| 资助者 | This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; This work has been supported by the program for New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Key Project of Chinese Ministry of Education (No. 107105). We also would like to acknowledge Scientific and Technological Projects of China (2009ZX09501-029, 2008ZX10005-005) and Yunnan (2007BC006), 863 Program (2006AA020602), 973 Program (2009CB522306), the CAS (KSCX1-YW-R-24, KSCX2-YW-R-185), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/4687 |
| 专题 | 科研部门_分子免疫药理学（郑永唐） 科研部门_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences; Kunming 650204, P.R. China 2.Graduate School of Chinese Academy of Sciences; Beijing 100039, P .R. China 3.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences; Kunming 650223, P.R. China. |
| 推荐引用方式 GB/T 7714 | Feng T,Wang RR,Cai XH,et al. Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):971-975. |
| APA | Feng T,Wang RR,Cai XH,Zheng YT*,Luo XD*,&zhengyt@mail.kiz.ac.cn.(2010).Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),971-975. |
| MLA | Feng T,et al."Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):971-975. |
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