| Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora | |
| Xiao WL1; Wang RR2; Zhao W1; Tian RR2; Shang SZ1; Yang LM2; Yang JH1; Pu JX1; Zheng YT2; Sun HD*1; hdsun@mail.kib.ac.cn | |
| 2010 | |
| 发表期刊 | ARCHIVES OF PHARMACAL RESEARCH
 |
| ISSN | 0253-6269 |
| 卷号 | 33期号:5页码:697-701 |
| 合作性质 | 其它 |
| 摘要 | This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 similar to 20.4 mu g/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively. |
| 关键词 | Schisandra Rubriflora Lignan Nmr Cd Spectrum Anti-hiv-1 Activity |
| 资助者 | This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). ; This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). ; This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). ; This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). ; This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). ; This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). ; This project was supported financially by the NSFC (No. 30830115 and 20802082), the projects from the Chinese Academy of Sciences (“Xibuzhiguang” to W.- L.X, KSCX1-YW-R-24, KSCX2-YW-R-185), 973 Pro- gram (No. 2009CB522300 and 2009CB940900), the Yong Academic and Technical Leader Rising Founda- tion of Yunnan Province (2006PY01-47) Key Scientific and Technology Projects of China (2009ZX09501-029). |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/4699 |
| 专题 | 科研部门_分子免疫药理学（郑永唐） 科研部门_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | hdsun@mail.kib.ac.cn |
| 作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Acad- emy of Sciences, Kunming 650204, Yunnan, China 2.Key Laboratory of Animal Models and Human Disease Mecha- nisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Xiao WL,Wang RR,Zhao W,et al. Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(5):697-701. |
| APA | Xiao WL.,Wang RR.,Zhao W.,Tian RR.,Shang SZ.,...&hdsun@mail.kib.ac.cn.(2010).Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora.ARCHIVES OF PHARMACAL RESEARCH,33(5),697-701. |
| MLA | Xiao WL,et al."Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora".ARCHIVES OF PHARMACAL RESEARCH 33.5(2010):697-701. |
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