| Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia | |
| Ueno H1,2; Nishigaki Y*1; Kong QP3; Fuku N1; Kojima S2; Iwata N4; Ozaki N5; Tanaka M1; yutakan@tmig.or.jp | |
| 2009 | |
| 发表期刊 | MITOCHONDRION
 |
| ISSN | 1567-7249 |
| 卷号 | 9期号:6页码:385-393 |
| 合作性质 | 其它 |
| 摘要 | To test the hypothesis that mitochondrial DNA (mtDNA) variants contribute to the susceptibility to schizophrenia, we sequenced the entire mtDNAs from 93 Japanese schizophrenic patients. Three non-synonymous homoplasmic variants in subunit six of the ATP synthase (MT-ATP6) gene that were detected only in patients but not in controls were suggested to be slightly deleterious, because (1) their original amino acid residues (AA) were highly conserved and (2) the physicochemical differences between the original and altered AA were relatively high. In addition, we detected three novel heteroplasmic variants that were potentially pathogenic. Although functional analysis is needed, rare variants in the mtDNA may convey susceptibility to schizophrenia. (C) 2009 Elsevier B.V. on behalf of Mitochondria Research Society. |
| 关键词 | Mitochondrial Dna Schizophrenia Polymorphism Variant Mutation |
| 资助者 | This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i ; This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i ; This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i ; This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i ; This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i ; This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i ; This work was supported in part by the Support Project for Database Development from the Japan Science and Technology Corporation (to M.T.); a Grant-in-Aid for Scientific Research [C-18590317 to Y.N., and C2-10832009 and A (2)-15200051 to M.T.], a Grant-i |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/4781 |
| 专题 | 科研部门_分子人类学（孔庆鹏） 遗传资源与进化国家重点实验室 |
| 通讯作者 | yutakan@tmig.or.jp |
| 作者单位 | 1.Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan 2.Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Department of Psychiatry, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi 470-1192, Japan 5.Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-Ku, Nagoya-shi, Aichi 466-8550, Japan |
| 推荐引用方式 GB/T 7714 | Ueno H,Nishigaki Y*,Kong QP,et al. Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia[J]. MITOCHONDRION,2009,9(6):385-393. |
| APA | Ueno H.,Nishigaki Y*.,Kong QP.,Fuku N.,Kojima S.,...&yutakan@tmig.or.jp.(2009).Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia.MITOCHONDRION,9(6),385-393. |
| MLA | Ueno H,et al."Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia".MITOCHONDRION 9.6(2009):385-393. |
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