Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila species

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	Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila species
	Wang W 1,2; Yu HJ 3; Long MY*2; mlong@midway.uchicago.edu
	2004
发表期刊	NATURE GENETICS
ISSN	1061-4036
卷号	36 期号:5 页码:523-527
合作性质	其它
摘要	Gene fission and fusion, the processes by which a single gene is split into two separate genes and two adjacent genes are fused into a single gene, respectively, are among the primary processes that generate new genes. Despite their seeming reversibility, nothing is known about the mechanism of gene fission. Because the nucleotide sequences of fission genes record little about their origination process, conventional analysis of duplicate genes may not be powerful enough to unravel the underlying mechanism. In a survey for young genes in species of the Drosophila melanogaster subgroup using fluorescence in situ hybridization, we identified a young gene family, monkey king, whose genesis sheds light on the evolutionary process of gene fission. Its members originated 1-2 million years ago as retroposed duplicates and evolved into fission genes that separately encode protein domains from a multidomain ancestor. The mechanism underlying this process is gene duplication with subsequent partial degeneration.
资助者	This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W. ; This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W. ; This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W. ; This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W.
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收录类别	SCI
语种	英语
资助者	This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W. ; This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W. ; This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W. ; This work was supported by a Packard Fellowship in Science and Engineering, a National Science Foundation CAREER award and a grant from the US National Institutes of Health to M.L, and a CAS-Max Planck Society Fellowship, a CAS key project grant and a National Science Foundation of China award to W.W.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4801
专题	基因起源组细胞与分子进化重点实验室
通讯作者	mlong@midway.uchicago.edu
作者单位	1.CAS-Max Planck Junior Scientist Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Department of Ecology and Evolution, The University of Chicago, 1101 E 57 th Street, Chicago, Illinois 60637, US 3.School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China
推荐引用方式 GB/T 7714	Wang W,Yu HJ,Long MY*,et al. Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila species[J]. NATURE GENETICS,2004,36(5):523-527.
APA	Wang W,Yu HJ,Long MY*,&mlong@midway.uchicago.edu.(2004).Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila species.NATURE GENETICS,36(5),523-527.
MLA	Wang W,et al."Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila species".NATURE GENETICS 36.5(2004):523-527.

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