Relaxation of yeast mitochondrial functions after whole-genome duplication

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	Relaxation of yeast mitochondrial functions after whole-genome duplication
	Jiang HF 1,2,3; Guan WJ 1,4; Pinney D 5; Wang W2; Gu ZL1; wwang@mail.kiz.ac.cn ; zg27@cornell.edu
	2008
发表期刊	GENOME RESEARCH
ISSN	1088-9051
卷号	18 期号:9 页码:1466-1471
合作性质	其它
摘要	Mitochondria are essential for cellular energy production in most eukaryotic organisms. However, when glucose is abundant, yeast species that underwent whole-genome duplication (WGD) mostly conduct fermentation even under aerobic conditions, and most can survive without a functional mitochondrial genome. In this study, we show that the rate of evolution for the nuclear-encoded mitochondrial genes was greater in post-WGD species than pre-WGD species. Furthermore, codon usage bias was relaxed for these genes in post-WGD yeast species. The codon usage pattern and the distribution of a particular transcription regulatory element suggest that the change to an efficient aerobic fermentation lifestyle in this lineage might have emerged after WGD between the divergence of Kluyveromyces polysporus and Saccharomyces castellii from their common ancestor. This new energy production strategy could have led to the relaxation of mitochondrial function in the relevant yeast species.
资助者	This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G. ; This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G. ; This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G. ; This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G.
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收录类别	SCI
语种	英语
资助者	This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G. ; This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G. ; This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G. ; This work was supported by a NSFC key grant (no. 30430400) and a 973 Program of China (no. 2007CB815703-5) to W.W. and startup funds from Cornell University awarded to Z.G.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4839
专题	基因起源组遗传资源与进化国家重点实验室
通讯作者	wwang@mail.kiz.ac.cn; zg27@cornell.edu
作者单位	1.Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA 2.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan 650223, People’s Republic of China 3.Graduate School of Chinese Academy Sciences, Beijing 100039, People’s Republic of China 4.Zhejiang University, College of Life Sciences, Hangzhou 310058, People’s Republic of China 5.Department of Mathematics, Cornell University, Ithaca, New York 14853, USA
推荐引用方式 GB/T 7714	Jiang HF,Guan WJ,Pinney D,et al. Relaxation of yeast mitochondrial functions after whole-genome duplication[J]. GENOME RESEARCH,2008,18(9):1466-1471.
APA	Jiang HF.,Guan WJ.,Pinney D.,Wang W.,Gu ZL.,...&zg27@cornell.edu.(2008).Relaxation of yeast mitochondrial functions after whole-genome duplication.GENOME RESEARCH,18(9),1466-1471.
MLA	Jiang HF,et al."Relaxation of yeast mitochondrial functions after whole-genome duplication".GENOME RESEARCH 18.9(2008):1466-1471.

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