Methylation and gene mutation in eukaryotic DNA

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	Methylation and gene mutation in eukaryotic DNA
	Liu CQ 1; Huang JF*1; Wang J 1; Liu WB 2; tbrg@public.km.yn.cn
	1998
发表期刊	ACTA BIOLOGICA HUNGARICA
ISSN	0236-5383
卷号	49 期号:2-4 页码:185-191
合作性质	其它
摘要	5-methylcytosine (m(5)C) as a rare base exists in eukaryotic genomes, which is a normal constitution in many eukaryotic DNA and the existence of m(5)C is a feature of eukaryotic DNA. Under regular physiological conditions, cytosine of eukaryotic DNA is usually methylated. Up to the present, many people consider that the m(5)C may be mutation hotspots by the deamination leading to gene mutation. Our study indicated that the spontaneous mutation caused by the transition of G.C --> A.T, in eukaryotic DNA, may result from the tautomer changing of base pairs and may also be cause by other factor actions, however it could not be caused by the deamination of m(5)C.
关键词	Dna Methylation 5-methylcytosine Deamination Gene Mutation Molecular Electrostatic Potential
学科领域	Biology
URL	查看原文
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4877
专题	结构生物信息学细胞与分子进化开放实验室
通讯作者	tbrg@public.km.yn.cn
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming, Yunnan, Peoples R China 2.Yunnan Univ, Modern Biol Ctr, Kunming 650091, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu CQ,Huang JF*,Wang J,et al. Methylation and gene mutation in eukaryotic DNA[J]. ACTA BIOLOGICA HUNGARICA,1998,49(2-4):185-191.
APA	Liu CQ,Huang JF*,Wang J,Liu WB,&tbrg@public.km.yn.cn.(1998).Methylation and gene mutation in eukaryotic DNA.ACTA BIOLOGICA HUNGARICA,49(2-4),185-191.
MLA	Liu CQ,et al."Methylation and gene mutation in eukaryotic DNA".ACTA BIOLOGICA HUNGARICA 49.2-4(1998):185-191.

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