Different protein tyrosine phosphatase superfamilies resulting from different gene reading frames

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	Different protein tyrosine phosphatase superfamilies resulting from different gene reading frames
	Huang JF*; hjf58117@public.km.yn.cn
	2003
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	20 期号:5 页码:815-820
合作性质	其它
摘要	Protein tyrosine phosphatases (PTPs) are comprised of two superfamilies, the phosphatase I superfamily containing a single low-molecular-weight PTP (lmwPTP) family and the phosphatase II superfamily including both the higher-molecular-weight PTP (hmwPTP) and the dual-specificity phosphatase (DSP) families. The phosphatase I and H superfamilies are often considered to be the result of convergent evolution. The PTP sequence and structure analyses indicate that lmwPTPs, hmwPTPs, and DSPs share similar structures, functions, and a common signature motif, although they have low sequence identities and a different order of active sites in sequence or a circular permutation. The results of this work suggest that lmwPTPs and hmwPTPs/DSPs are remotely related in evolution. The earliest ancestral gene of PTPs could be from a short fragment containing about 90similar to120 nucleotides or 30similar to40 residues; however, a probable full PTP ancestral gene contained one transcript unit with two lmwPTP genes. All three PTP families may have resulted from a common ancestral gene by a series of duplications, fusions, and circular permutations. The circular permutation in PTPs is caused by a reading frame difference, which is similar to that in DNA methyltransferases. Nevertheless, the evolutionary mechanism of circular permutation in PTP genes seems to be more complicated than that in DNA methyltransferase genes. Both mechanisms in PTPs and DNA methyltransferases can be used to explain how some protein families and superfamilies came to be formed by circular permutations during molecular evolution.
关键词	Circular Permutation Different Gene Reading Frames Divergent And Convergent Evolution Gene Duplication And Fusion Molecular Evolution
资助者	the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support. ; the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support. ; the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support. ; the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support.
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收录类别	SCI
语种	英语
资助者	the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support. ; the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support. ; the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support. ; the Natural Science Foundation of China (Grant 30170507; 30024004) and the Natural Science Foundation of Yunnan Province (Grant 1999C0084M) for financial support.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4899
专题	结构生物信息学细胞与分子进化重点实验室
通讯作者	hjf58117@public.km.yn.cn
作者单位	Yunnan Key Laboratory of Molecular Biology of Domestic Animals, and the Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China
推荐引用方式 GB/T 7714	Huang JF*,hjf58117@public.km.yn.cn. Different protein tyrosine phosphatase superfamilies resulting from different gene reading frames[J]. MOLECULAR BIOLOGY AND EVOLUTION,2003,20(5):815-820.
APA	Huang JF*,&hjf58117@public.km.yn.cn.(2003).Different protein tyrosine phosphatase superfamilies resulting from different gene reading frames.MOLECULAR BIOLOGY AND EVOLUTION,20(5),815-820.
MLA	Huang JF*,et al."Different protein tyrosine phosphatase superfamilies resulting from different gene reading frames".MOLECULAR BIOLOGY AND EVOLUTION 20.5(2003):815-820.

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