Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples

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	Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples
	Zhang SX 1,2; Wang X 1; Chen XF 3; Cao H 1; Zhang W 4; Liu CQ*1,5,6; liucq@ynu.edu.cn
	2008
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	53 期号:3 页码:377-383
合作性质	其它
摘要	Here we report the codon bias and the mRNA secondary structural features of the hemagglutinin (HA) cleavage site basic amino acid regions of avian influenza virus H5N1 subtypes. We have developed a dynamic extended folding strategy to predict RNA secondary structure with RNAstructure 4.1 program in an iterative extension process. Statistical analysis of the sequences showed that the HA cleavage site basic amino acids favor the adenine-rich codons, and the corresponding mRNA fragments are mainly in the folding states of single-stranded loops. Our sequential and structural analyses showed that to prevent and control these highly pathogenic viruses, that is, to inhibit the gene expression of avian influenza virus H5N1 subtypes, we should consider the single-stranded loop regions of the HA cleavage site-coding sequences as the targets of RNA interference.
关键词	Avian Influenza (Ai) Hemagglutinin (Ha) Cleavage Site Rna Secondary Structure Dynamic Extended Folding
资助者	Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08) ; Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08) ; Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08) ; Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08)
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收录类别	SCI
语种	英语
资助者	Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08) ; Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08) ; Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08) ; Supported by the National Natural Science Foundation of China (Grants No. 90208018, 39970412 and 90303018) and the CAS Knowledge Innovation Project Cross-Frontier Project (No. KJCX1-08)
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4907
专题	其他
通讯作者	liucq@ynu.edu.cn
作者单位	1.Modern Biological Research Center, Yunnan University, Kunming 650091, China 2.Henan Medical School, Kaifeng 475300, China 3.Tangdu Hospital, Fourth Military Medical University, Xi’an 710033, China 4.Deparment of Cell Biology and Medical Genetics, Kunming Medical College, Kunming 650031, China 5.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 6.Center for Theoretical Biology, Peking University, Beijing 100871, China
推荐引用方式 GB/T 7714	Zhang SX,Wang X,Chen XF,et al. Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples[J]. CHINESE SCIENCE BULLETIN,2008,53(3):377-383.
APA	Zhang SX.,Wang X.,Chen XF.,Cao H.,Zhang W.,...&liucq@ynu.edu.cn.(2008).Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples.CHINESE SCIENCE BULLETIN,53(3),377-383.
MLA	Zhang SX,et al."Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples".CHINESE SCIENCE BULLETIN 53.3(2008):377-383.

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